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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Trp73
transformation related protein 73
MGI:1336991
78 phenotypes from 5 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Trp73em1(IMPC)H/Trp73+
C57BL/6NTac-Trp73em1(IMPC)H/H 		decreased spleen weight J:211773
increased blood urea nitrogen level J:211773
thrombocytosis J:211773
Trp73em1(IMPC)H/Trp73em1(IMPC)H
C57BL/6NTac-Trp73em1(IMPC)H/H 		preweaning lethality, incomplete penetrance J:211773
Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
involves: 129S1/Sv * 129X1/SvJ 		abnormal choroid plexus morphology J:153209
abnormal cortical marginal zone morphology J:153209
abnormal forebrain development J:153209
abnormal hypothalamus morphology J:153209
abnormal trigeminal ganglion morphology J:153209
abnormal vomeronasal organ morphology J:153209
decreased Cajal-Retzius cell number J:153209
increased neuron apoptosis J:153209
reduced fertility J:153209
Trp73tm1Fmc/Trp73+
involves: 129S4/SvJae * C57BL/6 		increased hemangiosarcoma incidence J:98958
increased lung adenocarcinoma incidence J:98958
increased lung adenoma incidence J:98958
increased malignant tumor incidence J:98958
increased T cell derived lymphoma incidence J:98958
increased tumor incidence J:98958
premature death J:98958
Trp73tm1Fmc/Trp73tm1Fmc
involves: 129S4/SvJae 		abnormal cerebrospinal fluid production J:60896
abnormal dendrite morphology J:180144
abnormal dentate gyrus morphology J:60896, J:180144
abnormal hippocampal mossy fiber morphology J:180144
abnormal hippocampus CA3 region morphology J:180144
abnormal hippocampus development J:60896
abnormal hippocampus morphology J:180144
abnormal hippocampus neuron morphology J:180144
abnormal vomeronasal organ morphology J:60896
absent Cajal-Retzius cell J:60896
absent enterocytes J:60896
cachexia J:60896
chronic inflammation J:60896
conjunctivitis J:60896
decreased body size J:60896
dilated lateral ventricle J:60896
distended ileum J:60896
domed cranium J:60896
excessive digestive secretion J:60896
female infertility J:60896
gastrointestinal hemorrhage J:60896
hydrocephaly J:60896
increased susceptibility to bacterial infection J:60896
increased susceptibility to otitis media J:60896
intracranial hemorrhage J:60896
intraventricular hemorrhage J:60896
normal neoplasm J:60896
non-obstructive hydrocephaly J:60896
periorbital edema J:60896
postnatal lethality, incomplete penetrance J:60896
reduced male mating frequency J:60896
rhinitis J:60896
sinus inflammation J:60896
submission towards male mice J:60896
Trp73tm1Fmc/Trp73tm1Fmc
involves: 129S4/SvJae * C57BL/6 		increased lung adenocarcinoma incidence J:98958
premature death J:98958
Trp73tm1Mak/Trp73+
involves: 129P2/OlaHsd * C57BL/6J 		increased carcinoma incidence J:142848
increased hemangiosarcoma incidence J:142848
increased lung adenocarcinoma incidence J:142848
increased lymphoma incidence J:142848
increased T cell derived lymphoma incidence J:142848
Trp73tm1Mak/Trp73tm1Mak
involves: 129P2/OlaHsd 		abnormal dendrite morphology J:180144
Trp73tm1Mak/Trp73tm1Mak
involves: 129P2/OlaHsd * C57BL/6J 		abnormal cell cycle J:142848
abnormal chromosome number J:142848
abnormal dentate gyrus morphology J:142848
abnormal embryo development J:142848
abnormal hippocampus morphology J:142848
abnormal meiotic spindle morphology J:142848
abnormal ovarian follicle number J:142848
abnormal ovulation J:142848
abnormal spindle assembly in female meiosis J:142848
abnormal superovulation J:142848
decreased oocyte number J:142848
decreased primordial ovarian follicle number J:142848
failure of superovulation J:142848
female infertility J:142848
increased carcinoma incidence J:142848
increased incidence of tumors by chemical induction J:142848
increased lung adenocarcinoma incidence J:142848
increased lymphoma incidence J:142848
increased T cell derived lymphoma incidence J:142848
male infertility J:142848
maternal effect J:142848
polyploidy J:142848
premature death J:142848
prenatal lethality, incomplete penetrance J:142848
Trp73tm2Mak/Trp73tm2Mak
either: B6.129P2-Trp73tm2Mak or (involves: 129P2/OlaHsd * C57BL/6J) 		abnormal cerebral cortex morphology J:157905
decreased neuron number J:157905
increased cellular sensitivity to gamma-irradiation J:157905
increased physiological sensitivity to xenobiotic J:157905
increased sensitivity to induced cell death J:157905
increased thymocyte apoptosis J:157905
neurodegeneration J:157905
prenatal lethality, incomplete penetrance J:157905
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11/12/2024
MGI 6.24 		The Jackson Laboratory