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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lancl1
LanC (bacterial lantibiotic synthetase component C)-like 1
MGI:1336997
29 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lancl1em1Vdd/Lancl1em1Vdd
FVB/N-Lancl1em1Vdd 		no abnormal phenotype detected J:249809
Lancl1tm1.1Pfw/Lancl1tm1.1Pfw
involves: 129 * C57BL/6 		abnormal cauda epididymis morphology J:324139
abnormal mitochondrial physiology J:214805
abnormal redox activity J:324139
abnormal seminiferous tubule morphology J:324139
abnormal sperm mitochondrial morphology J:324139
abnormal sperm physiology J:324139
abnormal spermatocyte morphology J:324139
abnormal spermatogenesis J:324139
abnormal spermatogonia morphology J:324139
abnormal spermatogonia proliferation J:324139
asthenozoospermia J:324139
brain inflammation J:214805
decreased litter size J:324139
decreased male germ cell number J:324139
decreased sperm progressive motility J:324139
decreased testis weight J:324139
dilated mitochondrion J:324139
normal homeostasis/metabolism phenotype J:324139
increased male germ cell apoptosis J:324139
increased neuron apoptosis J:214805
increased sperm mitochondrial size J:324139
increased susceptibility to neuronal excitotoxicity J:214805
increased testis weight J:324139
neurodegeneration J:214805
oligozoospermia J:324139
oxidative stress J:214805, J:324139
reduced male fertility J:324139
testicular atrophy J:324139
Lancl1tm1Pfw/Lancl1tm1.1Pfw
Tg(Ddx4-cre)1Dcas/0
involves: 129 * C57BL/6 * FVB 		abnormal sperm physiology J:324139
abnormal spermatogenesis J:324139
asthenozoospermia J:324139
decreased male germ cell number J:324139
decreased sperm progressive motility J:324139
decreased testis weight J:324139
oligozoospermia J:324139
oxidative stress J:324139
reduced male fertility J:324139
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory