Rnf7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rnf7
ring finger protein 7
MGI:1337096

28 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rnf7^Gt(XE423)Byg/Rnf7^Gt(XE423)Byg involves: 129P2/OlaHsd	increased apoptosis	J:164457
	increased cellular sensitivity to ionizing radiation	J:164457
	oxidative stress	J:164457
Rnf7^Gt(XE423)Byg/Rnf7^Gt(XE423)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal cell cycle	J:178926
	abnormal cell differentiation	J:178926
	abnormal visceral yolk sac blood island morphology	J:178926
	abnormal vitelline vasculature morphology	J:178926
	decreased angiogenesis	J:178926
	decreased cell proliferation	J:178926
	embryonic growth retardation	J:178926
	embryonic lethality during organogenesis, complete penetrance	J:178926
	increased embryonic tissue cell apoptosis	J:178926
	increased spinal cord apoptosis	J:178926
	pericardial edema	J:178926
Rnf7^{tm1a(EUCOMM)Wtsi}/Rnf7⁺ Not Specified	abnormal response to tactile stimuli	J:165965
	decreased circulating chloride level	J:165965
	decreased circulating triglyceride level	J:165965
	increased circulating chloride level	J:165965
Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} involves: C57BL/6N	no abnormal phenotype detected	J:205551
Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} involves: C57BL/6N	abnormal neuronal migration	J:205551
Rnf7^{tm1c(EUCOMM)Wtsi}/Rnf7^{tm1c(EUCOMM)Wtsi} Tg(Nes-cre)1Kln/0 involves: C57BL/6 * C57BL/6N * SJL	abnormal cerebellar layer morphology	J:205551
	decreased cerebellar granule cell precursor proliferation	J:205551
	delaminated Purkinje cell layer	J:205551
	ectopic Purkinje cell	J:205551
	enlarged brain ventricles	J:205551
	hydrocephaly	J:205551
	postnatal growth retardation	J:205551
	small cerebellum	J:205551

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24