Rev3l Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rev3l
REV3 like, DNA directed polymerase zeta catalytic subunit
MGI:1337131

35 phenotypes from 10 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rev3l^tm1.1Kunk/Rev3l^tm1.1Kunk involves: C57BL/6	abnormal somatic hypermutation frequency	J:188723
Rev3l^tm1.1Kunk/Rev3l^tm1.1Kunk involves: C57BL/6	normal immune system phenotype	J:188723
Rev3l^{tm1b(EUCOMM)Hmgu}/Rev3l⁺ C57BL/6N-Rev3l^{tm1b(EUCOMM)Hmgu}/J	abnormal retina morphology	J:211773
	cataract	J:211773
	decreased blood urea nitrogen level	J:211773
	decreased circulating creatinine level	J:211773
	decreased mean corpuscular volume	J:211773
	hyperactivity	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
Rev3l^{tm1b(EUCOMM)Hmgu}/Rev3l^{tm1b(EUCOMM)Hmgu} C57BL/6N-Rev3l^{tm1b(EUCOMM)Hmgu}/J	preweaning lethality, complete penetrance	J:211773
Rev3l^tm1Esp/Rev3l^tm1Esp involves: C57BL/6	abnormal embryonic tissue morphology	J:65200
Rev3l^tm1Esp/Rev3l^tm1Esp involves: C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:65200
Rev3l^tm1Kaji/Rev3l^tm1Kaji involves: 129P2/OlaHsd * C57BL/6J	abnormal embryonic tissue morphology	J:74111
	embryonic growth arrest	J:74111
	embryonic lethality during organogenesis, complete penetrance	J:74111
	increased embryonic tissue cell apoptosis	J:74111
Rev3l^tm1Msn/Rev3l^tm1Msn Not Specified	decreased embryo size	J:65202
Rev3l^tm1Msn/Rev3l^tm1Msn Not Specified	embryonic lethality during organogenesis, complete penetrance	J:65202
Rev3l^tm1Ndew/Rev3l^tm1Ndew involves: 129P2/OlaHsd * C57BL/6	abnormal embryonic tissue morphology	J:75450
	embryonic lethality during organogenesis, complete penetrance	J:75450
	spontaneous chromosome breakage	J:75450
Rev3l^tm1Rsky/Rev3l^tm1.1Rsky Tg(Cr2-cre)3Cgn/? involves: C57BL/6	abnormal class switch recombination	J:146453
	abnormal somatic hypermutation frequency	J:146453
	decreased B cell proliferation	J:146453
	decreased germinal center B cell number	J:146453
	decreased IgG1 level	J:146453
	spontaneous chromosome breakage	J:146453
Rev3l^tm1Rwd/Rev3l^tm1Rwd involves: 129P2/OlaHsd	abnormal craniofacial development	J:65201
	abnormal embryonic neuroepithelium morphology	J:65201
	abnormal embryonic tissue morphology	J:65201
	abnormal mesenchyme morphology	J:65201
	abnormal somite shape	J:65201
	abnormal visceral yolk sac morphology	J:65201
	abnormal vitelline vasculature morphology	J:65201
	decreased embryo size	J:65201
	delayed embryo turning	J:65201
	embryonic growth retardation	J:65201
	embryonic lethality during organogenesis, complete penetrance	J:65201
	incomplete somite formation	J:65201
	increased cell death	J:65201
	neural tube degeneration	J:65201
	pericardial edema	J:65201
Rev3l^tm1Rwd/Rev3l^tm2.1Rwd Tg(MMTV-cre)1Mam/0 involves: 129P2/OlaHsd * C57BL/6 * FVB	increased carcinoma incidence	J:158922
	increased mammary gland tumor incidence	J:158922

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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