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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bcl10
B cell leukemia/lymphoma 10
MGI:1337994
37 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bcl10m1Btlr/Bcl10m1Btlr
C57BL/6J-Bcl10m1Btlr 		abnormal humoral immune response J:265122
decreased B-1 B cell number J:265122
decreased IgG level J:265122
increased CD4-positive, alpha-beta T cell number J:265122
increased IgE level J:265122
increased IgM level J:265122
increased single-positive T cell number J:265122
increased T cell number J:265122
Bcl10tm1Mak/Bcl10tm1Mak
involves: 129P2/OlaHsd 		abnormal cytotoxic T cell physiology J:67297
abnormal dendritic cell physiology J:111706
abnormal immune cell physiology J:67297
abnormal neural fold elevation formation J:67297
abnormal response to infection J:67297
abnormal T cell activation J:67297
abnormal T cell differentiation J:67297
normal cellular phenotype J:67297
decreased activated T cell number J:67297
decreased B cell proliferation J:67297, J:109545
decreased double-positive T cell number J:67297
decreased IgG level J:67297
decreased IgM level J:67297
decreased immunoglobulin level J:67297
decreased T cell proliferation J:67297, J:109545
decreased thymocyte number J:67297
exencephaly J:67297
increased double-negative T cell number J:67297
increased hindbrain apoptosis J:67297
increased susceptibility to infection J:67297
open neural tube J:67297
perinatal lethality, incomplete penetrance J:67297
Bcl10tm1Swm/Bcl10tm1Swm
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:85147
abnormal humoral immune response J:85147
abnormal marginal zone B cell physiology J:85147
decreased B cell number J:85147
decreased B cell proliferation J:85147
decreased B-1 B cell number J:85147
decreased follicular B cell number J:85147
decreased marginal zone B cell number J:85147
decreased mature B cell number J:85147
exencephaly J:85147
increased susceptibility to bacterial infection J:85147
perinatal lethality, incomplete penetrance J:85147
Bcl10tm1Swm/Bcl10tm1Swm
involves: 129P2/OlaHsd * C57BL/6 		abnormal cytokine secretion J:122394
abnormal dendritic cell physiology J:122394
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory