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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Irs4
insulin receptor substrate 4
MGI:1338009
17 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Irs1tm1Jos/Irs1tm1Jos
Irs4tm1Lhd/Y
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		impaired glucose tolerance J:80976
increased circulating insulin level J:80976
insulin resistance J:80976
postnatal growth retardation J:80976
Irs1tm1Jos/Irs1tm1Jos
Irs4tm1Lhd/Irs4tm1Lhd
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 		impaired glucose tolerance J:80976
increased circulating insulin level J:80976
insulin resistance J:80976
postnatal growth retardation J:80976
Irs2tm2Mfw/Irs2tm2Mfw
Irs4tm1.1Mfw/Y
Leprtm3(cre)Mgmj/Lepr+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal growth/size/body region phenotype J:221293
normal homeostasis/metabolism phenotype J:221293
Irs2tm2Mfw/Irs2tm2Mfw
Irs4tm1.1Mfw/Y
Tg(Nes-cre)1Kln/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal adipose tissue amount J:221293
abnormal glucose homeostasis J:221293
decreased basal metabolism J:221293
decreased oxygen consumption J:221293
hepatic steatosis J:221293
impaired glucose tolerance J:221293
increased body weight J:221293
increased brown fat cell lipid droplet size J:221293
increased circulating glucose level J:221293
increased circulating insulin level J:221293
increased circulating leptin level J:221293
increased fasting circulating glucose level J:221293
increased food intake J:221293
insulin resistance J:221293
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory