Hic1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hic1
hypermethylated in cancer 1
MGI:1338010

28 phenotypes from 4 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hic1^tm1.1Kori/Hic1^tm1.1Kori involves: 129S4/SvJae * C57BL/6 * SJL	no abnormal phenotype detected	J:170337
Hic1^tm1.2Kori/Hic1^tm1.2Kori involves: 129S4/SvJae * C57BL/6 * SJL	embryonic lethality during organogenesis, complete penetrance	J:170337
Hic1^tm1Sbb/Hic1⁺ involves: 129S4/SvJae * C57BL/6	dermatitis	J:81448
	increased carcinoma incidence	J:81448
	increased hepatocellular carcinoma incidence	J:81448
	increased lung adenocarcinoma incidence	J:81448
	increased lymphoma incidence	J:81448
	increased malignant tumor incidence	J:81448
	increased metastatic potential	J:81448
	increased pancreatic islet cell carcinoma incidence	J:81448
	increased sarcoma incidence	J:81448
	increased squamous cell carcinoma incidence	J:81448
Hic1^tm1Sbb/Hic1^tm1Sbb involves: 129S4/SvJae * C57BL/6	abnormal brain development	J:60589
	abnormal brain dura mater morphology	J:60589
	abnormal craniofacial development	J:60589
	abnormal forelimb morphology	J:60589
	abnormal hindlimb morphology	J:60589
	abnormal palate morphology	J:60589
	abnormal ventral body wall morphology	J:60589
	acrania	J:60589
	decreased embryo size	J:60589
	decreased fetal size	J:60589
	exencephaly	J:60589
	holoprosencephaly	J:60589
	lowered ear position	J:60589
	perinatal lethality, complete penetrance	J:60589
	short snout	J:60589
	small ears	J:60589
Hic1^tm2.1Kori/Hic1^tm2.1Kori involves: 129S4/SvJae * C57BL/6 * SJL	embryonic lethality during organogenesis, complete penetrance	J:170337

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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