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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mapk11
mitogen-activated protein kinase 11
MGI:1338024
23 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mapk11tm1Jda/Mapk11tm1Jda
Mapk14tm1Jda/Mapk14tm1Jda
involves: 129 * C57BL/6 		abnormal T-helper 1 cell differentiation J:165966
abnormal T-helper 2 cell differentiation J:165966
abnormal T-helper 17 cell differentiation J:165966
decreased interferon-gamma secretion J:165966
decreased susceptibility to experimental autoimmune encephalomyelitis J:165966
decreased susceptibility to induced arthritis J:165966
decreased T cell proliferation J:165966
decreased tumor necrosis factor secretion J:165966
increased interleukin-10 secretion J:165966
Mapk11tm1Jsca/Mapk11+
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		primary sex reversal J:191096
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm2Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal fetal cardiomyocyte proliferation J:176023
abnormal liver morphology J:176023
abnormal neuron proliferation J:176023
exencephaly J:176023
increased hepatocyte apoptosis J:176023
lethality throughout fetal growth and development, complete penetrance J:176023
primary sex reversal J:191096
small liver J:176023
spina bifida J:176023
ventricular septal defect J:176023
Mapk11tm1Jsca/Mapk11tm1Jsca
Mapk14tm2Nbr/Mapk14tm3.1(Mapk11)Nbr
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129P2/OlaHsd * C57BL/6 * CBA 		normal nervous system phenotype J:176023
postnatal lethality, complete penetrance J:176023
ventricular septal defect J:176023
Mapk11tm1Jsca/Mapk11tm1Jsca
Tnftm2Gkl/Tnf+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		autoimmune arthritis J:107771
ileum inflammation J:107771
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory