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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gdf11
growth differentiation factor 11
MGI:1338027
80 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gdf11tm1.1Vlcg/Gdf11tm1.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac 		increased rib number J:200671
normal limbs/digits/tail phenotype J:200671
Gdf11tm1.1Vlcg/Gdf11tm1.1Vlcg
Tg(Nanog-cre)#Vlcg/0
involves: 129S6/SvEvTac * C57BL/6NTac 		cleft palate J:200671
short tail J:200671
Gdf11tm1Clf/Gdf11tm1Clf
involves: 129X1/SvJ * CD-1 		abnormal hindlimb bud morphology J:81451
abnormal kidney development J:81451
abnormal neuron differentiation J:81451
abnormal olfactory epithelium morphology J:81451
abnormal olfactory sensory neuron morphology J:81451
abnormal optic nerve morphology J:99244
absent amacrine cells J:99244
absent retina inner plexiform layer J:99244
absent sacral vertebrae J:81451
absent tail J:81451
decreased caudal vertebrae number J:81451
decreased retina photoreceptor cell number J:99244
delayed optic fissure closure J:99244
increased neuronal precursor cell number J:99244
increased retina ganglion cell number J:99244
neonatal lethality, complete penetrance J:81451
vertebral transformation J:81451
Gdf11tm1Sjl/Gdf11+
involves: 129S1/Sv * 129X1/SvJ 		abnormal axial skeleton morphology J:55879
abnormal cervical vertebrae morphology J:55879
abnormal kidney development J:83365
absent ureter J:83365
asymmetric rib joints J:55879
increased rib number J:55879
lumbar vertebral transformation J:55879
single kidney J:83365
thoracic vertebral transformation J:55879
Gdf11tm1Sjl/Gdf11+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal sternocostal joint morphology J:201148
cleft palate J:201148
normal homeostasis/metabolism phenotype J:94455
increased pancreatic alpha cell mass J:94455
increased pancreatic islet number J:94455
increased rib number J:201148
small pancreatic islets J:94455
Gdf11tm1Sjl/Gdf11tm1Sjl
involves: 129S1/Sv * 129X1/SvJ 		abnormal anus morphology J:136243
abnormal axial skeleton morphology J:55879
abnormal caudal vertebrae morphology J:158173
abnormal hindlimb morphology J:55879
abnormal kidney development J:55879, J:83365
abnormal metanephros morphology J:83365
abnormal palate morphology J:55879, J:136243
abnormal rectum morphology J:136243
abnormal rib morphology J:55879
abnormal rostral-caudal axis patterning J:55879
abnormal sacral vertebrae morphology J:55879
abnormal spinal cord morphology J:136243
abnormal vertebrae morphology J:55879
abnormal vertebral column morphology J:136243
absent kidney J:83365, J:136243
absent tail J:136243
absent ureter J:83365
absent ureteric bud J:83365
asymmetric rib joints J:55879
normal cardiovascular system phenotype J:136243
caudal body truncation J:158173
cervical vertebral transformation J:55879
decreased caudal vertebrae number J:55879, J:158173
decreased nephron number J:83365
impaired branching involved in ureteric bud morphogenesis J:83365
increased apoptosis J:83365
increased lumbar vertebrae number J:158173
increased presacral vertebrae number J:55879
increased rib number J:55879, J:136243
increased thoracic vertebrae number J:136243, J:158173
normal limbs/digits/tail phenotype J:136243, J:158173
lumbar vertebral transformation J:55879
neonatal lethality J:158173
neonatal lethality, complete penetrance J:55879
omphalocele J:136243
normal respiratory system phenotype J:136243
short tail J:55879
single kidney J:83365
small kidney J:83365
thoracic vertebral transformation J:55879
vertebral transformation J:55879
Gdf11tm1Sjl/Gdf11tm1Sjl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal embryonic epiblast morphology J:272567
abnormal tail morphology J:272567
abnormal tailgut morphology J:272567
bifurcated tail J:272567
increased spinal cord size J:272567
Gdf11tm1Sjl/Gdf11tm1Sjl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal axial skeleton morphology J:201148
abnormal exocrine pancreas morphology J:94455
abnormal pancreas morphology J:94455
abnormal pancreatic beta cell differentiation J:94455
abnormal spleen morphology J:94455
abnormal sternocostal joint morphology J:201148
abnormal stomach epithelium morphology J:94455
abnormal stomach morphology J:94455
decreased pancreatic acinar cell number J:94455
decreased pancreatic beta cell mass J:94455
increased pancreatic alpha cell mass J:94455
increased rib number J:201148
pancreatic islet hyperplasia J:94455
small pancreatic islets J:94455
Gdf11tm1Sjl/Gdf11tm2.1Sjl
Tg(Myl1-cre)1Sjl/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * FVB * SJL/J 		normal muscle phenotype J:158173
Gdf11tm2.2Sjl/Gdf11+
involves: C57BL/6 * CBA * FVB 		increased thoracic vertebrae number J:158173
Gdf11tm2.2Sjl/Gdf11tm2.2Sjl
involves: C57BL/6 * CBA * FVB 		increased thoracic vertebrae number J:158173
Gdf11tm2b(EUCOMM)Hmgu/Gdf11+
C57BL/6N-Gdf11tm2b(EUCOMM)Hmgu/Bay 		abnormal retina morphology J:211773
increased cardiac stroke volume J:211773
Gdf11tm2b(EUCOMM)Hmgu/Gdf11tm2b(EUCOMM)Hmgu
C57BL/6N-Gdf11tm2b(EUCOMM)Hmgu/Bay 		abnormal craniofacial morphology J:211773
abnormal facial morphology J:211773
abnormal tail morphology J:211773
cleft palate J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory