Spint1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spint1
serine protease inhibitor, Kunitz type 1
MGI:1338033

30 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spint1^{Gt(OST380474)Lex}/Spint1^{Gt(OST380474)Lex} involves: 129S5/SvEvBrd	abnormal basement membrane morphology	J:118798
	abnormal placenta labyrinth morphology	J:118798
	abnormal placental labyrinth vasculature morphology	J:118798
	abnormal trophoblast layer morphology	J:118798
	normal embryo phenotype	J:118798
	embryonic lethality during organogenesis, complete penetrance	J:118798
Spint1^{tm1b(EUCOMM)Wtsi}/Spint1⁺ C57BL/6N-Spint1^{tm1b(EUCOMM)Wtsi}/Tcp	preweaning lethality, incomplete penetrance	J:211773
Spint1^{tm1b(EUCOMM)Wtsi}/Spint1^{tm1b(EUCOMM)Wtsi} C57BL/6N-Spint1^{tm1b(EUCOMM)Wtsi}/Tcp	preweaning lethality, complete penetrance	J:211773
Spint1^tm1Bug/Spint1^tm1Bug involves: 129S6/SvEvTac	absent placental labyrinth	J:188121
Spint1^tm1Bug/Spint1^tm1Bug involves: 129S6/SvEvTac	embryonic lethality during organogenesis, complete penetrance	J:188121
Spint1^tm1Bug/Spint1^tm1Bug involves: 129S6/SvEvTac * NIH Black Swiss	abnormal trophoblast layer morphology	J:142708
	absent placental labyrinth	J:142708
	embryonic growth retardation	J:142708
	embryonic lethality during organogenesis, complete penetrance	J:142708
Spint1^tm1Hk/Spint1^tm1Hk involves: C57BL/6 * CBA	abnormal chorionic plate morphology	J:99182
	abnormal placenta development	J:99182
	abnormal placenta morphology	J:99182
	abnormal placenta vasculature	J:99182
	abnormal placental transport	J:99182
	abnormal trophoblast giant cell morphology	J:99182
	absent placental labyrinth	J:99182
	embryonic growth arrest	J:99182
	embryonic lethality during organogenesis, complete penetrance	J:99182
	enlarged pericardium	J:99182
	increased embryonic tissue cell apoptosis	J:99182
Spint1^tm2.1Hk/Spint1^tm2.1Hk Tg(Vil1-cre)997Gum/0 involves: C57BL/6 * C57BL/6J * SJL	abnormal defecation	J:179937
	abnormal enterocyte proliferation	J:179937
	abnormal intestine physiology	J:179937
	abnormal large intestine crypts of Lieberkuhn morphology	J:179937
	diarrhea	J:179937
	increased enterocyte apoptosis	J:179937
	increased susceptibility to induced colitis	J:179937
	increased susceptibility to weight loss	J:179937
	increased susceptibility to xenobiotic induced morbidity/mortality	J:179937
	intestinal ulcer	J:179937
	small cecum	J:179937

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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