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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itgb8
integrin beta 8
MGI:1338035
40 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itgb8tm1b(KOMP)Wtsi/Itgb8+
C57BL/6N-Itgb8tm1b(KOMP)Wtsi/BayMmucd 		abnormal retina outer nuclear layer morphology J:211773
abnormal skin coloration J:211773
Itgb8tm1b(KOMP)Wtsi/Itgb8tm1b(KOMP)Wtsi
C57BL/6N-Itgb8tm1b(KOMP)Wtsi/BayMmucd 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Itgb8tm1Lfr/Itgb8tm1Lfr
either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6J) 		abnormal angiogenesis J:77682
abnormal blood vessel morphology J:77682
abnormal capillary morphology J:77682
abnormal cardiovascular system physiology J:77682
abnormal chorioallantoic fusion J:77682
abnormal embryonic/fetal subventricular zone morphology J:77682
abnormal extraembryonic tissue morphology J:77682
abnormal heart morphology J:77682
abnormal heart ventricle morphology J:77682
abnormal pericardial cavity morphology J:77682
abnormal placenta morphology J:77682
abnormal placenta vasculature J:77682
abnormal placental labyrinth vasculature morphology J:77682
abnormal radial glial cell morphology J:77682
abnormal visceral yolk sac morphology J:77682
abnormal vitelline vasculature morphology J:77682
absent floor plate J:77682
cleft palate J:77682
decreased embryo size J:77682
embryonic lethality during organogenesis, incomplete penetrance J:77682
failure of vascular branching J:77682
hemopericardium J:77682
hydrocephaly J:77682
impaired basement membrane formation J:77682
increased vascular endothelial cell number J:77682
intracerebral hemorrhage J:77682
palatal shelves fail to meet at midline J:77682
pale yolk sac J:77682
postnatal lethality, complete penetrance J:77682
thin placenta labyrinth J:77682
Itgb8tm1Lfr/Itgb8tm1Lfr
involves: 129/Sv * ICR 		abnormal brain vasculature morphology J:136106
enlarged brain ventricles J:136106
Itgb8tm1Lfr/Itgb8tm2Lfr
Neurod6tm1(cre)Kan/Neurod6+
involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:102190
Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Nes-cre)1Kln/0
involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL 		abnormal astrocyte morphology J:102190
abnormal blood vessel morphology J:102190
abnormal vascular endothelial cell morphology J:102190
intracranial hemorrhage J:102190
Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Nes-cre)1Wmz/0
involves: 129/Sv * 129X1/SvJ * C57BL/6 * SJL 		intracranial hemorrhage J:102190
Itgb8tm1Lfr/Itgb8tm2Lfr
Tg(Tek-cre)1Rwng/0
involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL 		no abnormal phenotype detected J:102190
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory