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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Klf5
Kruppel-like transcription factor 5
MGI:1338056
98 phenotypes from 8 alleles in 12 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Klf5Gt(XB751)Byg/Klf5+
B6.129P2-Klf5Gt(XB751)Byg 		abnormal large intestine crypts of Lieberkuhn morphology J:136125
abnormal response to infection J:136125
Klf5Gt(XB751)Byg/Klf5Gt(XB751)Byg
B6.129P2-Klf5Gt(XB751)Byg 		absent blastocoele J:168150
decreased inner cell mass proliferation J:168150
decreased trophectoderm cell proliferation J:168150
embryonic lethality before implantation, complete penetrance J:168150
failure of blastocyst to hatch from the zona pellucida J:168150
Klf5M1Btlr/Klf5M1Btlr
C57BL/6J-Klf5M1Btlr 		increased susceptibility to induced colitis J:265229
Klf5tm1.1Jtd/Klf5+
Tg(Pbsn-cre)4Prb/0
involves: C57BL/6 * DBA/2 		abnormal prostate gland anterior lobe morphology J:206639
abnormal prostate gland dorsolateral lobe morphology J:206639
abnormal prostate gland physiology J:206639
decreased prostate gland weight J:206639
normal neoplasm J:206639
prostate gland hyperplasia J:206639
Klf5tm1.1Jtd/Klf5tm1.1Jtd
involves: C57BL/6 		no abnormal phenotype detected J:206639
Klf5tm1.1Jtd/Klf5tm1.1Jtd
Tg(Pbsn-cre)4Prb/0
involves: C57BL/6 * DBA/2 		abnormal prostate gland physiology J:206639
decreased prostate gland weight J:206639
normal neoplasm J:206639
prostate gland hyperplasia J:206639
Klf5tm1.1Jwel/Klf5tm1.1Jwel
Not Specified 		absent blastocoele J:168150
decreased inner cell mass proliferation J:168150
decreased trophectoderm cell proliferation J:168150
embryonic lethality before implantation, complete penetrance J:168150
failure of blastocyst to hatch from the zona pellucida J:168150
Klf5tm1Jaw/Klf5tm1Jaw
Pgrtm2(cre)Lyd/Pgr+
involves: 129S1/Sv * 129X1/SvJ 		abnormal decidualization J:179912
abnormal embryo attachment J:179912
abnormal uterine receptivity J:179912
decreased litter size J:179912
failure of embryo implantation J:179912
female infertility J:179912
normal homeostasis/metabolism phenotype J:179912
impaired embryo implantation J:179912
reduced female fertility J:179912
Klf5tm1Jaw/Klf5tm1Jaw
Tg(Pax6-cre,GFP)1Pgr/0
involves: FVB 		abnormal conjunctival epithelium morphology J:175263
abnormal cornea morphology J:175263
abnormal cornea stroma morphology J:175263
abnormal extraocular muscle morphology J:175263
abnormal eyelid aperture J:175263
abnormal eyelid morphology J:175263
abnormal iris morphology J:175263
abnormal lacrimal gland morphology J:175263
abnormal lens epithelium morphology J:175263
abnormal lens morphology J:175263
abnormal Meibomian gland acinus morphology J:175263
abnormal Meibomian gland development J:175263
abnormal Meibomian gland physiology J:175263
abnormal ocular surface morphology J:175263
abnormal palpebral conjunctiva morphology J:175263
absent conjunctiva goblet cells J:175263
anterior iris synechia J:175263
cornea opacity J:175263
decreased cornea epithelium thickness J:175263
disorganized secondary lens fibers J:175263
enlarged hair follicles J:175263
enlarged sebaceous gland J:175263
eyelid edema J:175263
increased cell proliferation J:175263
increased cornea stroma thickness J:175263
increased cornea thickness J:175263
lacrimal gland inflammation J:175263
lacrimal gland necrosis J:175263
microphthalmia J:175263
narrow eye opening J:175263
posterior iris synechia J:175263
small lens J:175263
small pupil J:175263
Klf5tm1Jaw/Klf5tm1Jaw
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * C57BL/6 		abnormal lung development J:138576
abnormal lung saccule morphology J:138576
abnormal pulmonary alveolus morphology J:138576
abnormal surfactant secretion J:138576
abnormal type I pneumocyte morphology J:138576
abnormal type II pneumocyte morphology J:138576
absent alveolar lamellar bodies J:138576
decreased type I pneumocyte number J:138576
neonatal lethality, complete penetrance J:138576
respiratory distress J:138576
thick lung-associated mesenchyme J:138576
Klf5tm1Rng/Klf5+
involves: 129 		cardiac fibrosis J:156696
cardiac hypertrophy J:156696
decreased heart weight J:156696
decreased response of heart to induced stress J:156696
Klf5tm1Rng/Klf5+
involves: 129/Sv * C57BL/6 		abnormal aorta wall morphology J:78275
abnormal intestinal mucosa morphology J:78275
abnormal small intestinal villus morphology J:78275
abnormal vascular smooth muscle physiology J:78275
abnormal vascular wound healing J:78275
decreased angiogenesis J:78275
decreased response of heart to induced stress J:78275
Klf5tm1Rng/Klf5tm1Rng
involves: 129/Sv * C57BL/6 		embryonic lethality, complete penetrance J:78275
Klf5tm1Yfk/Klf5tm1Yfk
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR) 		abnormal inner cell mass morphology J:149868
abnormal trophectoderm morphology J:149868
embryonic lethality at implantation, complete penetrance J:149868
failure of embryo implantation J:149868
Klf5tm2.1Rng/Klf5tm2.1Rng
involves: C57BL/6 		no abnormal phenotype detected J:156696
Klf5tm2.1Rng/Klf5tm2.1Rng
Tg(Myh6-cre)2182Mds/0
involves: C57BL/6 * FVB/N 		normal cardiovascular system phenotype J:156696
Klf5tm2.1Rng/Klf5tm2.1Rng
Tg(Postn-cre)1Sjc/0
involves: C57BL/6 		abnormal cardiovascular system physiology J:156696
abnormal heart left ventricle morphology J:156696
abnormal myocardial fiber morphology J:156696
abnormal myocardial fiber physiology J:156696
abnormal response of heart to induced stress J:156696
cardiac hypertrophy J:156696
cardiac interstitial fibrosis J:156696
decreased heart weight J:156696
increased heart left ventricle size J:156696
increased pulmonary respiratory rate J:156696
increased susceptibility to induced morbidity/mortality J:156696
increased susceptibility to xenobiotic induced morbidity/mortality J:156696
increased wet-to-dry lung weight ratio J:156696
pulmonary alveolar edema J:156696
pulmonary edema J:156696
pulmonary vascular congestion J:156696
weight loss J:156696
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory