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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdpk1
3-phosphoinositide dependent protein kinase 1
MGI:1338068
101 phenotypes from 10 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdpk1Gt(OST82857)Lex/Pdpk1Gt(OST82857)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		prenatal lethality, complete penetrance J:103485
Pdpk1tm1.1Daca/Pdpk1tm1.1Daca
involves: 129P2/OlaHsd * BALB/c 		embryonic lethality during organogenesis, complete penetrance J:165626
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw
involves: BALB/c 		no abnormal phenotype detected J:85894
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw
Tg(Ckmm-cre)5Khn/?
involves: BALB/c 		abnormal cardiovascular system morphology J:85498
abnormal cardiovascular system physiology J:85498
abnormal heart morphology J:85498
abnormal heart right ventricle morphology J:85498
abnormal heart ventricle morphology J:85498
abnormal myocardial fiber morphology J:85498
abnormal Z line morphology J:85498
decreased body weight J:85498
decreased cardiac muscle contractility J:85498
dilated cardiomyopathy J:85498
heart right ventricle hypertrophy J:85498
increased heart atrium size J:85498
myocardium hypoplasia J:85498
premature death J:85498
small heart J:85498
thin ventricular wall J:85498
Pdpk1tm1.2Mlw/Pdpk1tm1.2Mlw
involves: BALB/c 		abnormal allantois morphology J:85894
abnormal cephalic neural fold morphology J:85894
abnormal embryonic tissue morphology J:85894
abnormal endoderm development J:85894
abnormal head development J:85894
abnormal neural crest cell physiology J:85894
abnormal presomitic mesoderm morphology J:85894
abnormal rostral-caudal body axis extension J:85894
absent dorsal root ganglion J:85894
absent forebrain J:85894
absent heart J:85894
absent heart tube J:85894
absent pharyngeal arches J:85894
absent somites J:85894
anophthalmia J:85894
decreased embryo size J:85894
embryonic lethality during organogenesis, complete penetrance J:85894
incomplete embryo turning J:85894
small allantois J:85894
Pdpk1tm1Dral/Pdpk1tm1Dral
B6.129P2-Pdpk1tm1Dral 		abnormal kidney size J:136089
decreased adrenal gland zona fasciculata size J:136089
decreased body weight J:136089
decreased brain size J:136089
impaired glucose tolerance J:136089
increased circulating insulin level J:136089
insulin resistance J:136089
pancreatic islet hyperplasia J:136089
pancreatic islet hypoplasia J:136089
small pancreas J:136089
small spleen J:136089
small testis J:136089
Pdpk1tm1Ejm/Pdpk1tm1Ejm
involves: 129P2/OlaHsd * BALB/c 		abnormal brain development J:90081
abnormal embryo development J:90081
abnormal extraembryonic tissue morphology J:90081
abnormal first pharyngeal arch morphology J:90081
abnormal forebrain morphology J:90081
abnormal placenta development J:90081
abnormal vasculogenesis J:90081
absent dorsal root ganglion J:90081
decreased embryo size J:90081
decreased forebrain size J:90081
embryonic lethality during organogenesis, complete penetrance J:90081
Pdpk1tm1Jcbr/Pdpk1tm1Jcbr
Tg(Pomc1-cre)16Lowl/0
involves: C57BL/6 * FVB/N 		abnormal circulating leptin level J:134336
abnormal glucose homeostasis J:134336
abnormal melanotroph morphology J:134336
decreased circulating corticosterone level J:134336
decreased circulating glucose level J:134336
decreased corticotroph cell number J:134336
decreased gonadal fat pad weight J:134336
decreased insulin secretion J:134336
improved glucose tolerance J:134336
increased body weight J:134336
increased circulating glucose level J:134336
increased insulin sensitivity J:134336
polyphagia J:134336
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Alb1-cre)1Dlr/0
involves: 129S4/SvJae * FVB/N 		abnormal glucose homeostasis J:109359
impaired glucose tolerance J:109359
increased circulating glucose level J:109359
increased circulating insulin level J:109359
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(CAG-cat,-lacZ)11Miya/0
Tg(Pomc1-cre)16Lowl/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N 		abnormal neuron physiology J:162892
abnormal pituitary intermediate lobe morphology J:162892
decreased circulating corticosterone level J:162892
decreased response to leptin J:162892
hypoglycemia J:162892
increased corticotroph apoptosis J:162892
increased food intake J:162892
increased insulin sensitivity J:162892
increased melanotroph apoptosis J:162892
increased pituitary gland apoptosis J:162892
increased total body fat amount J:162892
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0
involves: 129S4/SvJae * C57BL/6J * CBA/J 		abnormal pancreas physiology J:109010
abnormal pancreatic beta cell morphology J:109010
decreased body weight J:109010
decreased circulating insulin level J:109010
hyperglycemia J:109010
increased circulating glucose level J:109010
premature death J:109010
small pancreatic islets J:109010
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Zp3-cre)93Knw/0
involves: 129S4/SvJae * C57BL/6J 		female infertility J:165798
maternal effect J:165798
Pdpk1tm1Mlw/Pdpk1tm1.1Daca
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2 		abnormal CD8-positive, alpha beta T cell morphology J:165626
decreased NK T cell number J:165626
decreased T cell number J:165626
Pdpk1tm1Mlw/Pdpk1tm1.2Mlw
involves: BALB/c 		decreased body size J:85894
prenatal lethality, incomplete penetrance J:85894
Pdpk1tm1Mlw/Pdpk1tm1Mlw
involves: BALB/c 		decreased birth body size J:85894
decreased body size J:85894
decreased body weight J:85894
prenatal lethality, incomplete penetrance J:85894
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		abnormal CD8-positive, alpha beta T cell morphology J:165626
abnormal NK T cell morphology J:165626
abnormal T cell differentiation J:165626
absent NK T cells J:165626
decreased NK T cell number J:165626
decreased T cell number J:165626
decreased T cell proliferation J:165626
normal immune system phenotype J:165626
Pdpk1tm2Ejm/Pdpk1+
involves: 129P2/OlaHsd * BALB/c 		prenatal lethality, incomplete penetrance J:90081
Pdpk1tm2Ejm/Pdpk1tm2Ejm
involves: 129P2/OlaHsd * BALB/c 		abnormal brain development J:90081
abnormal developmental patterning J:90081
normal cardiovascular system phenotype J:90081
decreased forebrain size J:90081
normal embryo phenotype J:90081
embryonic growth retardation J:90081
embryonic lethality during organogenesis, complete penetrance J:90081
normal nervous system phenotype J:90081
Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Not Specified 		abnormal glucose homeostasis J:170965
hyperglycemia J:170965
increased circulating insulin level J:170965
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory