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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdpk1
3-phosphoinositide dependent protein kinase 1
MGI:1338068
43 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Foxo1tm1Whb/Foxo1+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(Ins2-cre)23Herr/0
involves: 129S4/SvJae * C57BL/6J * CBA/J 		abnormal pancreas physiology J:109010
decreased circulating glucose level J:109010
increased circulating insulin level J:109010
increased pancreatic beta cell number J:109010
Gt(ROSA)26Sortm1(CAG-Foxo1*)Jcbr/Gt(ROSA)26Sor+
Pdpk1tm1Jcbr/Pdpk1tm1Jcbr
Tg(Pomc1-cre)16Lowl/0
involves: C57BL/6 * FVB/N 		decreased circulating corticosterone level J:134336
decreased corticotroph cell number J:134336
normal homeostasis/metabolism phenotype J:134336
Gt(ROSA)26Sortm1(Foxo1)Jnk/Gt(ROSA)26Sor+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(CAG-cat,-lacZ)11Miya/0
Tg(Pomc1-cre)16Lowl/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N 		increased body weight J:162892
Gt(ROSA)26Sortm2(Foxo1)Jnk/Gt(ROSA)26Sor+
Pdpk1tm1Maka/Pdpk1tm1Maka
Tg(CAG-cat,-lacZ)11Miya/0
Tg(Pomc1-cre)16Lowl/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N 		increased body weight J:162892
increased food intake J:162892
increased total body fat amount J:162892
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae * 129S6/SvEvTac 		normal endocrine/exocrine gland phenotype J:197054
normal neoplasm J:197054
Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S6/SvEvTac 		normal endocrine/exocrine gland phenotype J:197054
normal neoplasm J:197054
Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Ptf1atm1(cre)Hnak/Ptf1a+
involves: 129S4/SvJae 		abnormal pancreas morphology J:197054
normal neoplasm J:197054
Krastm4Tyj/Kras+
Pdpk1tm1Mlw/Pdpk1tm1Mlw
Tg(Cela1-cre/ERT)1Dam/0
involves: 129S4/SvJae 		increased lung non-small cell carcinoma incidence J:197054
normal neoplasm J:197054
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw
Rag2tm1Fwa/Rag2tm1Fwa
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		abnormal keratinocyte differentiation J:226194
dermatitis J:226194
epidermal hyperplasia J:226194
premature death J:226194
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129X1/SvJ * C57BL/6 		abnormal hypodermis fat layer morphology J:226194
abnormal keratinocyte differentiation J:226194
abnormal regulatory T cell number J:226194
abnormal T cell physiology J:226194
cachexia J:226194
dermatitis J:226194
enlarged lymph nodes J:226194
enlarged spleen J:226194
epidermal hyperplasia J:226194
hair follicle degeneration J:226194
hyperkeratosis J:226194
impaired skin barrier function J:226194
premature death J:226194
premature hair loss J:226194
scaly skin J:226194
skin fibrosis J:226194
skin hyperplasia J:226194
skin lesions J:226194
thick skin J:226194
Pdpk1tm1Bcol/Pdpk1tm1Bcol
involves: 129P2/OlaHsd * C57BL/6 * CBA 		abnormal craniofacial morphology J:102388
abnormal eye pigmentation J:102388
abnormal forelimb morphology J:102388
decreased embryo size J:102388
perinatal lethality, complete penetrance J:102388
short mandible J:102388
Pdpk1tm1Maka/Pdpk1tm1Maka
Ptentm1Hwu/Ptentm1Hwu
Tg(Zp3-cre)93Knw/0
involves: 129S4/SvJae * C57BL/6J 		normal reproductive system phenotype J:165798
Pdpk1tm1Maka/Pdpk1tm1Maka
Stat3tm2Aki/Stat3tm2Aki
Tg(Alb1-cre)1Dlr/0
involves: 129S4/SvJae * 129P2/OlaHsd * FVB/N 		abnormal glucose homeostasis J:109359
impaired glucose tolerance J:109359
Pdpk1tm1Maka/Pdpk1tm1Maka
Tsc1tm1Djk/Tsc1tm1Djk
Tg(Gdf9-icre)5092Coo/?
involves: 129S4/SvJae * C57BL/6J 		abnormal ovarian follicle morphology J:155357
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory