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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Itsn1
intersectin 1 (SH3 domain protein 1A)
MGI:1338069
30 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Itsn1em1(IMPC)H/Itsn1+
C57BL/6NTac-Itsn1em1(IMPC)H/H 		decreased exploration in new environment J:211773
Itsn1em1(IMPC)H/Itsn1em1(IMPC)H
C57BL/6NTac-Itsn1em1(IMPC)H/H 		abnormal gait J:211773
abnormal skin coloration J:211773
decreased prepulse inhibition J:211773
increased circulating alkaline phosphatase level J:211773
increased circulating amylase level J:211773
increased circulating iron level J:211773
increased circulating serum albumin level J:211773
increased circulating total protein level J:211773
limb grasping J:211773
Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz
129.129S2-Itsn1Gt(pT1ATGBetageo)1Ruiz 		abnormal anterior commissure morphology J:196062
abnormal brain white matter morphology J:196062
abnormal corpus callosum morphology J:196062
abnormal hippocampal fimbria morphology J:196062
abnormal hippocampal fornix morphology J:196062
abnormal spatial learning J:196062
decreased anterior commissure size J:196062
decreased body size J:196062
decreased body weight J:196062
decreased brain size J:196062
impaired contextual conditioning behavior J:196062
impaired coordination J:196062
normal nervous system phenotype J:196062
postnatal growth retardation J:196062
Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz
involves: 129S2/SvPas * C57BL/6 		prenatal lethality, complete penetrance J:85162
Itsn1tm1.1Mapr/Itsn1tm1.1Mapr
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal adrenal gland secretion J:140030
abnormal cell morphology J:140030
abnormal synaptic vesicle recycling J:140030
decreased body size J:140030
decreased survivor rate J:140030
postnatal growth retardation J:140030
premature death J:140030
Itsn1tm2.1Mapr/Itsn1tm2.1Mapr
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal adrenal gland secretion J:140030
abnormal cell morphology J:140030
abnormal synaptic vesicle recycling J:140030
decreased body size J:140030
decreased survivor rate J:140030
postnatal growth retardation J:140030
premature death J:140030
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory