Ikbkb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ikbkb
inhibitor of kappaB kinase beta
MGI:1338071

80 phenotypes from 16 alleles in 19 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Ikbkb^tm2Mka/Ikbkb^tm2Mka involves: 129/Sv * 129P2/OlaHsd * C57BL/6	abnormal B cell activation	J:82995
	decreased B cell number	J:82995
	decreased B cell proliferation	J:82995
	decreased B-1 B cell number	J:82995
	decreased IgG level	J:82995
	decreased IgM level	J:82995
	decreased marginal zone B cell number	J:82995
	increased B cell apoptosis	J:82995
Cd19^tm1(cre)Cgn/Cd19⁺ Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn involves: 129P2/OlaHsd * C57BL/6	decreased B-1 B cell number	J:79132
	decreased follicular B cell number	J:79132
	decreased marginal zone B cell number	J:79132
	decreased mature B cell number	J:79132
Cd19^tm1(cre)Cgn/Cd19⁺ Ikbkb^tm1Cgn/Ikbkb^tm1.1Cgn involves: 129P2/OlaHsd * C57BL/6	decreased B-1 B cell number	J:79132
	decreased follicular B cell number	J:79132
	decreased immature B cell number	J:79132
	decreased marginal zone B cell number	J:79132
	decreased mature B cell number	J:79132
	increased B cell proliferation	J:79132
Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal B cell physiology	J:113365
	abnormal splenic cell ratio	J:113365
	decreased B cell apoptosis	J:113365
	increased B cell number	J:113365
	increased cell proliferation	J:113365
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Ikbkb^tm1Lex/Ikbkb^tm1Lex involves: 129S/SvEvBrd	abnormal fibroblast migration	J:159873
	decreased fibroblast cell migration	J:159873
	decreased fibroblast chemotaxis	J:159873
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal spleen morphology	J:167612
	decreased germinal center B cell number	J:167612
	enlarged spleen	J:167612
	increased B cell number	J:167612
	increased IgG1 level	J:167612
	increased IgM level	J:167612
	increased plasma cell number	J:167612
Ikbkb^em1Macc/Ikbkb⁺ involves: C57BL/6NCrl	abnormal effector T cell number	J:290616
	abnormal T cell activation	J:290616
	decreased B cell number	J:290616
	decreased CD4-positive, alpha-beta T cell number	J:290616
	decreased CD8-positive, alpha-beta T cell number	J:290616
	decreased memory B cell number	J:290616
	decreased T cell number	J:290616
	increased regulatory T cell number	J:290616
Ikbkb^em1Macc/Ikbkb^em1Macc involves: C57BL/6NCrl	abnormal effector T cell number	J:290616
	abnormal T cell activation	J:290616
	decreased B cell number	J:290616
	decreased CD4-positive, alpha-beta T cell number	J:290616
	decreased CD8-positive, alpha-beta T cell number	J:290616
	decreased memory B cell number	J:290616
	decreased T cell number	J:290616
	increased regulatory T cell number	J:290616
Ikbkb^em1Smoc/Ikbkb^em1Smoc C57BL/6J-Ikbkb^em1Smoc	normal behavior/neurological phenotype	J:309163
	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:309163
	normal embryo phenotype	J:309163
	normal reproductive system phenotype	J:309163
Ikbkb^M1Btlr/Ikbkb⁺ C57BL/6J-Ikbkb^M1Btlr	abnormal B cell physiology	J:225271
	abnormal CD8-positive, alpha-beta T cell differentiation	J:225271
	abnormal response to infection	J:225271
	increased response to antigen	J:225271
Ikbkb^M1Btlr/Ikbkb^M1Btlr C57BL/6J-Ikbkb^M1Btlr	abnormal B cell physiology	J:225271
	abnormal CD8-positive, alpha-beta T cell differentiation	J:225271
	increased susceptibility to viral infection	J:225271
Ikbkb^M2Btlr/Ikbkb^M2Btlr C57BL/6J-Ikbkb^M2Btlr	decreased central memory CD4-positive, alpha-beta T cell number	J:274802
Ikbkb^tm1.1Cgn/Ikbkb^tm1.1Cgn involves: C57BL/6	decreased interleukin-6 secretion	J:79132, J:85810
	increased fibroblast apoptosis	J:85810
	prenatal lethality, complete penetrance	J:85810
Ikbkb^{tm1a(EUCOMM)Wtsi}/Ikbkb⁺ B6JTyr;B6N-Ikbkb^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased body weight	J:165965
	increased body weight	J:165965
Ikbkb^{tm1a(EUCOMM)Wtsi}/Ikbkb^{tm1a(EUCOMM)Wtsi} B6JTyr;B6N-Ikbkb^{tm1a(EUCOMM)Wtsi}/Wtsi	preweaning lethality, incomplete penetrance	J:211773
Ikbkb^tm1Cgn/Ikbkb^tm1.1Cgn Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:85810
	decreased CD8-positive, alpha-beta T cell number	J:85810
	decreased single-positive T cell number	J:85810
	decreased T cell number	J:85810
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn involves: C57BL/6	no abnormal phenotype detected	J:85810
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(KRT14-cre)1Cgn/0 involves: C57BL/6 * DBA/2	psoriasis	J:208995
	skin inflammation	J:208995
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tg(Lck-cre)I57Jxm/0 involves: C57BL/6 * ICR	decreased CD4-positive, alpha-beta T cell number	J:85810
	decreased CD8-positive, alpha-beta T cell number	J:85810
Ikbkb^tm1Lex/Ikbkb^tm1Lex Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd * 129S/SvEvBrd	impaired macrophage chemotaxis	J:159873
	impaired neutrophil chemotaxis	J:159873
	impaired neutrophil recruitment	J:159873
Ikbkb^tm1Mka/Ikbkb^tm1Mka involves: 129S6/SvEvTac * C57BL/6	abnormal hepatocyte morphology	J:55737
	embryonic lethality during organogenesis, complete penetrance	J:55737
	liver degeneration	J:55737
Ikbkb^tm1Trk/Ikbkb^tm1Trk involves: 129S1/Sv * C57BL/6	abnormal cell physiology	J:55680
	abnormal hepatocyte morphology	J:55680
	increased fibroblast apoptosis	J:55680
	increased hepatocyte apoptosis	J:55680
	lethality throughout fetal growth and development, complete penetrance	J:55680
	liver degeneration	J:55680
Ikbkb^tm1Ver/Ikbkb^tm1Ver involves: 129S4/SvJae * C57BL/6J	abnormal cell physiology	J:54323
	dissociated hepatocytes	J:54323
	embryonic lethality during organogenesis, complete penetrance	J:54323
	increased fibroblast apoptosis	J:54323
	increased hepatocyte apoptosis	J:54323
	liver degeneration	J:54323
	liver hemorrhage	J:54323
	small liver	J:54323
Ikbkb^tm2.1Cgn/Ikbkb^tm2.1Cgn involves: C57BL/6	decreased interleukin-6 secretion	J:79132
Ikbkb^tm2Cgn/Ikbkb^tm2.1Cgn Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal humoral immune response	J:85810
	decreased CD4-positive, alpha-beta T cell number	J:85810
	decreased CD8-positive, alpha-beta T cell number	J:85810
	decreased IgE level	J:85810
Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Alb1-cre)7Gsc/0 involves: C57BL/6 * FVB/N	abnormal enzyme/coenzyme activity	J:118336
	normal liver/biliary system phenotype	J:118336
Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	decreased CD4-positive, alpha-beta T cell number	J:85810
	decreased memory T cell number	J:85810
	decreased regulatory T cell number	J:85810
Ikbkb^tm2Mka/Ikbkb^tm2.1Mka Tg(Vil-cre)1Mka/0 involves: 129	increased cellular sensitivity to gamma-irradiation	J:88644
Ikbkb^tm2Mka/Ikbkb^tm2.1Mka Tg(Vil-cre)1Mka/0 involves: 129	increased enterocyte apoptosis	J:88644
Ikbkb^tm2Mka/Ikbkb^tm2.1Mka Tg(Vil-cre)1Mka/0 involves: 129/Sv * C57BL/6	abnormal intestinal mucosa morphology	J:83313
	abnormal response to injury	J:83313
	decreased acute inflammation	J:83313
	decreased circulating tumor necrosis factor level	J:83313
	impaired neutrophil recruitment	J:83313
	intestinal edema	J:83313
Ikbkb^tm2Mka/Ikbkb^tm2Mka Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129/Sv * 129P2/OlaHsd	increased macrophage apoptosis	J:80159
Ikbkb^tm2Mka/Ikbkb^tm2Mka Tg(Ckmm-cre)1Lrsn/0 involves: 129	abnormal myotube morphology	J:135692
Ikbkb^tm2Mka/Ikbkb^tm2Mka Tg(Ckmm-cre)1Lrsn/0 involves: 129	increased skeletal muscle fiber number	J:135692

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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