Ikbkb Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ikbkb
inhibitor of kappaB kinase beta
MGI:1338071

41 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19^tm1(cre)Cgn/Cd19⁺ Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass involves: 129P2/OlaHsd * C57BL/6	normal immune system phenotype	J:113365
Chuk^tm1Mpa/Chuk^tm1Mpa Ikbkb^tm2Cgn/Ikbkb^tm2Cgn Tg(Alb1-cre)7Gsc/0 involves: C57BL/6 * FVB/N	abnormal bile canaliculus morphology	J:137861
	abnormal bile duct morphology	J:137861
	cachexia	J:137861
	decreased survivor rate	J:137861
	increased circulating alanine transaminase level	J:137861
	increased circulating bilirubin level	J:137861
	increased susceptibility to endotoxin shock	J:137861
	intrahepatic cholestasis	J:137861
	jaundice	J:137861
	postnatal growth retardation	J:137861
	premature death	J:137861
Chuk^tm1Ver/Chuk^tm1Ver Ikbkb^tm1Ver/Ikbkb^tm1Ver involves: 129S4/SvJae * C57BL/6J	abnormal cell physiology	J:63443
	abnormal dorsal root ganglion morphology	J:63443
	abnormal hindbrain morphology	J:63443
	abnormal neural fold elevation formation	J:63443
	embryonic lethality during organogenesis, complete penetrance	J:63443
	increased embryonic neuroepithelium apoptosis	J:63443
	increased hepatocyte apoptosis	J:63443
	increased hindbrain apoptosis	J:63443
	increased spinal cord apoptosis	J:63443
	liver degeneration	J:63443
	open neural tube	J:63443
	small embryonic telencephalon	J:63443
Chuk^tm1Ver/Chuk^tm1Ver Ikbkb^tm1Ver/Ikbkb^tm1Ver Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak involves: 129/Sv * 129S4/SvJae * C57BL/6J	broad limb buds	J:63443
	curly tail	J:63443
	lethality throughout fetal growth and development, complete penetrance	J:63443
	open neural tube	J:63443
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ Prdm1^tm2Masu/Prdm1^tm2Masu involves: 129P2/OlaHsd * C57BL/6	abnormal germinal center B cell physiology	J:167612
	abnormal plasma cell differentiation	J:167612
	decreased IgG1 level	J:167612
	decreased survivor rate	J:167612
	increased B cell derived lymphoma incidence	J:167612
	increased germinal center B cell number	J:167612
	premature death	J:167612
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0 involves: 129P2/OlaHsd * C57BL/6	increased B cell number	J:157297
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Il20ra^tm1Rsab/Il20ra^tm1Rsab Tg(KRT14-cre)1Cgn/0 involves: C57BL/6 * DBA/2	premature death	J:208995
	skin inflammation	J:208995
	skin lesions	J:208995
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Il22^tm1Jcrd/Il22^tm1Jcrd Tg(KRT14-cre)1Cgn/0 involves: C57BL/6 * DBA/2	postnatal lethality, incomplete penetrance	J:208995
	skin inflammation	J:208995
	skin lesions	J:208995
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Il22ra1^tm1Rsab/Il22ra1^tm1Rsab Tg(KRT14-cre)1Cgn/0 involves: C57BL/6 * DBA/2	epidermal hyperplasia	J:208995
	normal mortality/aging	J:208995
	skin inflammation	J:208995
	skin lesions	J:208995
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	normal integument phenotype	J:208995
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak Tg(KRT14-cre)1Cgn/0 involves: 129S2/SvPas * C57BL/6 * DBA/2	normal integument phenotype	J:208995
Ikbkb^tm1Cgn/Ikbkb^tm1Cgn Tnfrsf1a^tm2Gkl/Tnfrsf1a^tm2Gkl Tg(KRT14-cre)1Cgn/0 involves: 129S/SvEv * C57BL/6 * DBA/2	epidermal hyperplasia	J:208995
	skin inflammation	J:208995
	skin lesions	J:208995
Ikbkb^tm1Ver/Ikbkb^tm1Ver Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak involves: 129S2/SvPas * 129S4/SvJae * C57BL/6J	postnatal lethality	J:54323
Sh3kbp1^tm1Kuro/Sh3kbp1^tm1Kuro Cd79a^tm1(cre)Reth/Cd79a⁺ Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/? involves: BALB/c * C57BL/6 * NZB	decreased B-1a cell number	J:176805
	normal immune system phenotype	J:176805

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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