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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ikbkg
inhibitor of kappaB kinase gamma
MGI:1338074
94 phenotypes from 8 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Ikbkgtm1.1Mpa/Y
involves: 129P2/OlaHsd * C57BL/6 		decreased B-1 B cell number J:79132
decreased follicular B cell number J:79132
decreased immature B cell number J:79132
decreased marginal zone B cell number J:79132
decreased mature B cell number J:79132
increased B cell proliferation J:79132
Ikbkgm1Btlr/Ikbkg+
C57BL/6J-Ikbkgm1Btlr 		reduced female fertility J:139558
Ikbkgm1Btlr/Y
C57BL/6J-Ikbkgm1Btlr 		azoospermia J:139558
decreased regulatory T cell number J:139558
decreased tumor necrosis factor secretion J:139558
normal immune system phenotype J:139558
normal mortality/aging J:139558
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
involves: C57BL/6 * SJL 		no abnormal phenotype detected J:151485
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
Tg(Alb1-cre)7Gsc/0
involves: C57BL/6 * FVB/N * SJL 		abnormal liver morphology J:151485
abnormal NK cell physiology J:151485
abnormal NK T cell physiology J:151485
decreased NK cell number J:151485
decreased NK T cell number J:151485
hepatic necrosis J:151485
hepatic steatosis J:151485
increased circulating alanine transaminase level J:151485
increased circulating tumor necrosis factor level J:151485
increased hepatocellular carcinoma incidence J:151485
increased hepatocyte apoptosis J:151485
increased interferon-gamma secretion J:151485
increased liver weight J:151485
increased physiological sensitivity to xenobiotic J:151485
increased susceptibility to xenobiotic induced morbidity/mortality J:151485
liver inflammation J:151485
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
Tg(Alb1-cre)7Gsc/0
involves: FVB/N 		abnormal liver morphology J:160521
normal homeostasis/metabolism phenotype J:160521
increased circulating alanine transaminase level J:160521
increased circulating aspartate transaminase level J:160521
increased circulating glutamate dehydrogenase level J:160521
increased hepatocellular carcinoma incidence J:160521
increased hepatocyte apoptosis J:160521
increased hepatocyte proliferation J:160521
liver fibrosis J:160521
normal liver/biliary system phenotype J:160521
Ikbkgtm1.1Chtr/Y
Tg(Alb1-cre)7Gsc/0
involves: C57BL/6 * FVB/N * SJL 		abnormal liver morphology J:151485
abnormal NK cell physiology J:151485
abnormal NK T cell physiology J:151485
abnormal response/metabolism to endogenous compounds J:151485
decreased NK cell number J:151485
decreased NK T cell number J:151485
decreased physiological sensitivity to xenobiotic J:151485
decreased susceptibility to xenobiotic induced morbidity/mortality J:151485
hepatic steatosis J:151485
increased circulating alanine transaminase level J:151485
increased hepatocellular carcinoma incidence J:151485
increased hepatocyte apoptosis J:151485
increased interferon-gamma secretion J:151485
increased liver weight J:151485
liver inflammation J:151485
Ikbkgtm1.1Dwat/Ikbkg+
B6.Cg-Ikbkgtm1.1Dwat 		abnormal fertility/fecundity J:202106
decreased B cell number J:202106
enlarged spleen J:202106
hyperkeratosis J:202106
parakeratosis J:202106
spontaneous skin ulceration J:202106
Ikbkgtm1.1Dwat/Y
B6.Cg-Ikbkgtm1.1Dwat 		preweaning lethality, complete penetrance J:202106
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 		abnormal B cell differentiation J:113365
decreased B cell number J:113365
decreased mature B cell number J:113365
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Tg(Alb1-cre)7Gsc/0
involves: C57BL/6 * FVB/N 		abnormal cytokine secretion J:118336
abnormal enzyme/coenzyme activity J:118336
abnormal hepatocyte mitochondrial morphology J:118336
abnormal hepatocyte morphology J:118336
abnormal inflammatory response J:118336
abnormal liver morphology J:118336
decreased circulating glucose level J:118336
hepatic steatosis J:118336
increased apoptosis J:118336
increased cell proliferation J:118336
increased circulating alanine transaminase level J:118336
increased hepatocellular carcinoma incidence J:118336
increased susceptibility to endotoxin shock J:137861
liver inflammation J:118336
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Tg(Vil1-cre)997Gum/0
B6.Cg-Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum 		colitis J:175865
crypts of Lieberkuhn abscesses J:175865
Ikbkgtm1.1Mpa/Y
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:85810
decreased CD8-positive, alpha-beta T cell number J:85810
decreased single-positive T cell number J:85810
decreased T cell number J:85810
increased T cell apoptosis J:85810
Ikbkgtm1.1Mpa/Y
Tg(Vil1-cre)997Gum/0
B6.Cg-Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum 		colitis J:175865
crypts of Lieberkuhn abscesses J:175865
Ikbkgtm1Dwb/Ikbkgtm1Dwb
Not Specified 		abnormal chemokine secretion J:136353
abnormal humoral immune response J:136353
decreased interleukin-6 secretion J:136353
decreased interleukin-12b secretion J:136353
decreased susceptibility to endotoxin shock J:136353
decreased tumor necrosis factor secretion J:136353
Ikbkgtm1Mak/Y
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:61666
increased fibroblast apoptosis J:61666
increased hepatocyte apoptosis J:61666
increased interleukin-6 secretion J:61666
liver hemorrhage J:61666
Ikbkgtm1Mka/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal liver morphology J:63054
embryonic lethality during organogenesis, complete penetrance J:63054
increased hepatocyte apoptosis J:63054
Ikbkgtm1Mka/Ikbkg+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal bone marrow cell morphology/development J:63054
abnormal locomotor behavior J:63054
absent megakaryocytes J:63054
absent subcutaneous adipose tissue J:63054
decreased body weight J:63054
erythroderma J:63054
hyperkeratosis J:63054
increased apoptosis J:63054
increased hepatocyte apoptosis J:63054
increased keratinocyte apoptosis J:63054
parakeratosis J:63054
postnatal lethality, incomplete penetrance J:63054
small spleen J:63054
small thymus J:63054
sparse hair J:63054
tremors J:63054
Ikbkgtm1Mpa/Y
involves: C57BL/6 		decreased interleukin-6 secretion J:63055
decreased tumor necrosis factor secretion J:63055
increased fibroblast apoptosis J:63055
prenatal lethality, complete penetrance J:63055
Ikbkgtm1Mpa/Ikbkg+
involves: C57BL/6 		abnormal dermal pigmentation J:63055
abnormal epidermal pigmentation J:63055
abnormal epidermis stratum basale morphology J:63055
abnormal epidermis suprabasal layer morphology J:63055
abnormal keratinocyte morphology J:63055
increased keratinocyte apoptosis J:63055
parakeratosis J:63055
postnatal growth retardation J:63055
postnatal lethality, incomplete penetrance J:63055
retarded hair growth J:63055
scaly skin J:63055
skin inflammation J:63055
thick epidermis J:63055
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory