About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ikbkg
inhibitor of kappaB kinase gamma
MGI:1338074
94 phenotypes from 8 alleles in 13 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Ikbkgtm1.1Mpa/Y
involves: 129P2/OlaHsd * C57BL/6 		decreased B-1 B cell number J:79132
decreased follicular B cell number J:79132
decreased immature B cell number J:79132
decreased marginal zone B cell number J:79132
decreased mature B cell number J:79132
increased B cell proliferation J:79132
Ikbkgm1Btlr/Ikbkg+
C57BL/6J-Ikbkgm1Btlr 		reduced female fertility J:139558
Ikbkgm1Btlr/Y
C57BL/6J-Ikbkgm1Btlr 		azoospermia J:139558
decreased regulatory T cell number J:139558
decreased tumor necrosis factor secretion J:139558
normal immune system phenotype J:139558
normal mortality/aging J:139558
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
involves: C57BL/6 * SJL 		no abnormal phenotype detected J:151485
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
Tg(Alb1-cre)7Gsc/0
involves: C57BL/6 * FVB/N * SJL 		abnormal liver morphology J:151485
abnormal NK cell physiology J:151485
abnormal NK T cell physiology J:151485
decreased NK cell number J:151485
decreased NK T cell number J:151485
hepatic necrosis J:151485
hepatic steatosis J:151485
increased circulating alanine transaminase level J:151485
increased circulating tumor necrosis factor level J:151485
increased hepatocellular carcinoma incidence J:151485
increased hepatocyte apoptosis J:151485
increased interferon-gamma secretion J:151485
increased liver weight J:151485
increased physiological sensitivity to xenobiotic J:151485
increased susceptibility to xenobiotic induced morbidity/mortality J:151485
liver inflammation J:151485
Ikbkgtm1.1Chtr/Ikbkgtm1.1Chtr
Tg(Alb1-cre)7Gsc/0
involves: FVB/N 		abnormal liver morphology J:160521
normal homeostasis/metabolism phenotype J:160521
increased circulating alanine transaminase level J:160521
increased circulating aspartate transaminase level J:160521
increased circulating glutamate dehydrogenase level J:160521
increased hepatocellular carcinoma incidence J:160521
increased hepatocyte apoptosis J:160521
increased hepatocyte proliferation J:160521
liver fibrosis J:160521
normal liver/biliary system phenotype J:160521
Ikbkgtm1.1Chtr/Y
Tg(Alb1-cre)7Gsc/0
involves: C57BL/6 * FVB/N * SJL 		abnormal liver morphology J:151485
abnormal NK cell physiology J:151485
abnormal NK T cell physiology J:151485
abnormal response/metabolism to endogenous compounds J:151485
decreased NK cell number J:151485
decreased NK T cell number J:151485
decreased physiological sensitivity to xenobiotic J:151485
decreased susceptibility to xenobiotic induced morbidity/mortality J:151485
hepatic steatosis J:151485
increased circulating alanine transaminase level J:151485
increased hepatocellular carcinoma incidence J:151485
increased hepatocyte apoptosis J:151485
increased interferon-gamma secretion J:151485
increased liver weight J:151485
liver inflammation J:151485
Ikbkgtm1.1Dwat/Ikbkg+
B6.Cg-Ikbkgtm1.1Dwat 		abnormal fertility/fecundity J:202106
decreased B cell number J:202106
enlarged spleen J:202106
hyperkeratosis J:202106
parakeratosis J:202106
spontaneous skin ulceration J:202106
Ikbkgtm1.1Dwat/Y
B6.Cg-Ikbkgtm1.1Dwat 		preweaning lethality, complete penetrance J:202106
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Cd79atm1(cre)Reth/Cd79a+
involves: BALB/c * C57BL/6 		abnormal B cell differentiation J:113365
decreased B cell number J:113365
decreased mature B cell number J:113365
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Tg(Alb1-cre)7Gsc/0
involves: C57BL/6 * FVB/N 		abnormal cytokine secretion J:118336
abnormal enzyme/coenzyme activity J:118336
abnormal hepatocyte mitochondrial morphology J:118336
abnormal hepatocyte morphology J:118336
abnormal inflammatory response J:118336
abnormal liver morphology J:118336
decreased circulating glucose level J:118336
hepatic steatosis J:118336
increased apoptosis J:118336
increased cell proliferation J:118336
increased circulating alanine transaminase level J:118336
increased hepatocellular carcinoma incidence J:118336
increased susceptibility to endotoxin shock J:137861
liver inflammation J:118336
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Tg(Vil1-cre)997Gum/0
B6.Cg-Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum 		colitis J:175865
crypts of Lieberkuhn abscesses J:175865
Ikbkgtm1.1Mpa/Y
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		decreased CD4-positive, alpha-beta T cell number J:85810
decreased CD8-positive, alpha-beta T cell number J:85810
decreased single-positive T cell number J:85810
decreased T cell number J:85810
increased T cell apoptosis J:85810
Ikbkgtm1.1Mpa/Y
Tg(Vil1-cre)997Gum/0
B6.Cg-Ikbkgtm1.1Mpa Tg(Vil1-cre)997Gum 		colitis J:175865
crypts of Lieberkuhn abscesses J:175865
Ikbkgtm1Dwb/Ikbkgtm1Dwb
Not Specified 		abnormal chemokine secretion J:136353
abnormal humoral immune response J:136353
decreased interleukin-6 secretion J:136353
decreased interleukin-12b secretion J:136353
decreased susceptibility to endotoxin shock J:136353
decreased tumor necrosis factor secretion J:136353
Ikbkgtm1Mak/Y
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:61666
increased fibroblast apoptosis J:61666
increased hepatocyte apoptosis J:61666
increased interleukin-6 secretion J:61666
liver hemorrhage J:61666
Ikbkgtm1Mka/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal liver morphology J:63054
embryonic lethality during organogenesis, complete penetrance J:63054
increased hepatocyte apoptosis J:63054
Ikbkgtm1Mka/Ikbkg+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal bone marrow cell morphology/development J:63054
abnormal locomotor behavior J:63054
absent megakaryocytes J:63054
absent subcutaneous adipose tissue J:63054
decreased body weight J:63054
erythroderma J:63054
hyperkeratosis J:63054
increased apoptosis J:63054
increased hepatocyte apoptosis J:63054
increased keratinocyte apoptosis J:63054
parakeratosis J:63054
postnatal lethality, incomplete penetrance J:63054
small spleen J:63054
small thymus J:63054
sparse hair J:63054
tremors J:63054
Ikbkgtm1Mpa/Y
involves: C57BL/6 		decreased interleukin-6 secretion J:63055
decreased tumor necrosis factor secretion J:63055
increased fibroblast apoptosis J:63055
prenatal lethality, complete penetrance J:63055
Ikbkgtm1Mpa/Ikbkg+
involves: C57BL/6 		abnormal dermal pigmentation J:63055
abnormal epidermal pigmentation J:63055
abnormal epidermis stratum basale morphology J:63055
abnormal epidermis suprabasal layer morphology J:63055
abnormal keratinocyte morphology J:63055
increased keratinocyte apoptosis J:63055
parakeratosis J:63055
postnatal growth retardation J:63055
postnatal lethality, incomplete penetrance J:63055
retarded hair growth J:63055
scaly skin J:63055
skin inflammation J:63055
thick epidermis J:63055
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory