Aire Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aire
autoimmune regulator
MGI:1338803

86 phenotypes from 9 alleles in 20 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aire^{tm1.1(cre)Ghr}/Aire^{tm1.1(cre)Ghr} Not Specified	decreased dendritic cell number	J:176844
	decreased regulatory T cell number	J:176844
	increased dendritic cell number	J:176844
Aire^{tm1.1(NCOM)Mfgc}/Aire⁺ C57BL/6N-Aire^{tm1.1(NCOM)Mfgc}/Tcp	abnormal cholesterol homeostasis	J:211773
Aire^{tm1.1(NCOM)Mfgc}/Aire^{tm1.1(NCOM)Mfgc} C57BL/6N-Aire^{tm1.1(NCOM)Mfgc}/Tcp	abnormal eye morphology	J:211773
	abnormal retina morphology	J:211773
	decreased prepulse inhibition	J:211773
	increased monocyte cell number	J:211773
Aire^tm1.1Doi/Aire^tm1.1Doi (B6.129S2-Aire^tm1.1Doi x NOD.129S2(B6)-Aire^tm1.1Doi)F1	normal digestive/alimentary phenotype	J:107432
Aire^tm1.1Doi/Aire^tm1.1Doi B6.129S2-Aire^tm1.1Doi/Doi	increased autoantibody level	J:107432
	increased incidence of corneal inflammation	J:107432
	lung inflammation	J:107432
	retina degeneration	J:107432
	salivary gland inflammation	J:107432
	stomach inflammation	J:107432
Aire^tm1.1Doi/Aire^tm1.1Doi C.129S2-Aire^tm1.1Doi/Doi	increased autoantibody level	J:107432
	increased incidence of corneal inflammation	J:107432
	liver inflammation	J:107432
	lung inflammation	J:107432
	ovary inflammation	J:107432
	prostate gland inflammation	J:107432
	retina degeneration	J:107432
	salivary gland inflammation	J:107432
	stomach inflammation	J:107432
Aire^tm1.1Doi/Aire^tm1.1Doi involves: 129S2/SvPas * C57BL/6	abnormal thymus medulla morphology	J:83422
	increased autoantibody level	J:119475
	increased susceptibility to autoimmune disorder	J:83422
	increased T cell number	J:83422
	stomach inflammation	J:119475
Aire^tm1.1Doi/Aire^tm1.1Doi involves: 129S2/SvPas * C57BL/6 * NOD	liver inflammation	J:107432
	lung inflammation	J:107432
	pancreas inflammation	J:107432
	salivary gland inflammation	J:107432
	stomach inflammation	J:107432
Aire^tm1.1Doi/Aire^tm1.1Doi NOD.129S2(B6)-Aire^tm1.1Doi/Doi	cachexia	J:107432
	increased autoantibody level	J:107432
	increased incidence of corneal inflammation	J:107432
	liver inflammation	J:107432
	lung inflammation	J:107432
	ovary inflammation	J:107432
	pancreas inflammation	J:107432
	premature death	J:107432
	prostate gland inflammation	J:107432
	retina degeneration	J:107432
	salivary gland inflammation	J:107432
	stomach inflammation	J:107432
	thyroid gland inflammation	J:107432
Aire^tm1.1Doi/Aire^tm1.1Doi NOD.129S2-Aire^tm1.1Doi	abnormal CD4-positive, alpha-beta T cell physiology	J:135154
	chronic pancreas inflammation	J:135154
	insulitis	J:135154
	lacrimal gland inflammation	J:135154
	lung inflammation	J:135154
	salivary gland inflammation	J:135154
	stomach inflammation	J:135154
	thyroid gland inflammation	J:135154
	uveitis	J:135154
Aire^tm1.1Doi/Aire^tm1.1Doi SJL.129S2-Aire^tm1.1Doi/Doi	increased autoantibody level	J:107432
	liver inflammation	J:107432
	lung inflammation	J:107432
	ovary inflammation	J:107432
	pancreas inflammation	J:107432
	prostate gland inflammation	J:107432
	salivary gland inflammation	J:107432
	stomach inflammation	J:107432
Aire^tm1Mand/Aire⁺ involves: 129P2/OlaHsd * C57BL/6	lacrimal gland inflammation	J:135154
Aire^tm1Mand/Aire⁺ involves: 129P2/OlaHsd * C57BL/6	salivary gland inflammation	J:135154
Aire^tm1Mand/Aire⁺ NOD.129P2-Aire^tm1Mand	abnormal CD4-positive, alpha-beta T cell physiology	J:135154, J:188686
	abnormal chemokine level	J:188686
	abnormal nervous system morphology	J:188686
	abnormal sciatic nerve morphology	J:135154, J:188686
	chronic pancreas inflammation	J:135154
	CNS inflammation	J:135154
	demyelination	J:188686
	hindlimb paralysis	J:135154
	increased autoantibody level	J:188686
	increased CXCL10 level	J:188686
	increased inflammatory response	J:188686
	increased susceptibility to autoimmune diabetes	J:135154, J:188686
	insulitis	J:135154
	lacrimal gland inflammation	J:135154
	limb grasping	J:188686
	paralysis	J:188686
	salivary gland inflammation	J:135154
	thyroid gland inflammation	J:135154
Aire^tm1Mand/Aire^tm1.1Doi NOD.129-Aire^tm1Mand/Aire^tm1.1Doi	abnormal CD4-positive, alpha-beta T cell physiology	J:135154
	chronic pancreas inflammation	J:135154
	insulitis	J:135154
	lacrimal gland inflammation	J:135154
	lung inflammation	J:135154
	salivary gland inflammation	J:135154
	stomach inflammation	J:135154
	thyroid gland inflammation	J:135154
	uveitis	J:135154
	weight loss	J:135154
Aire^tm1Mand/Aire^tm1Mand involves: 129P2/OlaHsd * C57BL/6	eye inflammation	J:135154
	lacrimal gland inflammation	J:135154
	salivary gland inflammation	J:135154
Aire^tm1Mmat/Aire^tm1Mmat B6.Cg-Aire^tm1Mmat	autoimmune response	J:96580
Aire^tm1Mmat/Aire^tm1Mmat B6.Cg-Aire^tm1Mmat	salivary gland inflammation	J:96580
Aire^tm1Mmat/Aire^tm1Mmat C.Cg-Aire^tm1Mmat	abnormal stomach mucosa morphology	J:96580
	increased autoantibody level	J:96580
	stomach inflammation	J:96580
Aire^tm1Mmat/Aire^tm1Mmat involves: C57BL/6 * CBA	autoimmune response	J:96580
	decreased tear production	J:96580
	normal endocrine/exocrine gland phenotype	J:96580
	lacrimal gland inflammation	J:96580
	pancreas inflammation	J:96580
	parotid gland inflammation	J:96580
	reduced fertility	J:96580
	stomach inflammation	J:96580
	submandibular gland inflammation	J:96580
Aire^tm1Mmat/Aire^tm2Mmat involves: C57BL/6 * CBA	abnormal thymus morphology	J:141379
Aire^tm1Mmat/Aire^tm2Mmat involves: C57BL/6 * CBA	autoimmune response	J:141379
Aire^tm1Pltn/Aire⁺ involves: 129S4/SvJae * C57BL/6	reduced fertility	J:77873
Aire^tm1Pltn/Aire^tm1Pltn B6.129S4-Aire^tm1Pltn	abnormal definitive hematopoiesis	J:115076
	abnormal metallophilic macrophage morphology	J:115076
	abnormal myelopoiesis	J:115076
	abnormal spleen marginal zone morphology	J:115076
	decreased body weight	J:115076
	decreased follicular B cell number	J:115076
	enlarged spleen	J:115076
	normal immune system phenotype	J:115076
	increased B cell derived lymphoma incidence	J:115076
	increased B cell number	J:115076
	increased marginal zone B cell number	J:115076
	increased monocyte cell number	J:115076
	increased spleen weight	J:115076
	liver inflammation	J:115076
Aire^tm1Pltn/Aire^tm1Pltn involves: 129S4/SvJae * C57BL/6	abnormal T cell morphology	J:77873
	absent adrenal gland	J:77873
	increased autoantibody level	J:77873
	increased T cell proliferation	J:77873
	infertility	J:77873
	liver inflammation	J:77873
	thymus atrophy	J:77873
Aire^tm1Ptsn/Aire^tm1Ptsn C57BL/6-Aire^tm1Ptsn	abnormal T cell activation	J:145910
	abnormal thymus medulla morphology	J:145910
	increased autoantibody level	J:145910
	parotid gland inflammation	J:145910
	reduced male fertility	J:145910
	sublingual gland inflammation	J:145910
	uveitis	J:145910
	vitreous body inflammation	J:145910
Aire^tm1Ptsn/Aire^tm1Ptsn C.B6-Aire^tm1Ptsn	abnormal adaptive immunity	J:174653
	abnormal cytokine level	J:174653
	abnormal regulatory T cell physiology	J:174653
	abnormal T-helper 1 physiology	J:174653
	abnormal T-helper 17 cell physiology	J:174653
	decreased susceptibility to fungal infection	J:174653
	increased interleukin-6 secretion	J:174653
	increased interleukin-12 secretion	J:174653
	increased interleukin-23 secretion	J:174653
	increased susceptibility to autoimmune disorder	J:174653
	increased susceptibility to fungal infection	J:174653
	increased tumor necrosis factor secretion	J:174653
	stomach inflammation	J:174653
Aire^tm2Mmat/Aire^tm2Mmat involves: C57BL/6 * CBA	abnormal thymus morphology	J:141379
	abnormal thymus physiology	J:141379
	absent Hassall's corpuscle	J:141379
	autoimmune response	J:141379
Aire^tm3(cre)Mmat/? Not Specified	no abnormal phenotype detected	J:160217

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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