Aire Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aire
autoimmune regulator
MGI:1338803

14 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Aire^tm1.1Doi/Aire^tm1.1Doi H2^b/H2^b NOD.Cg-Aire^tm1.1Doi H2^b/Doi	abnormal pancreas physiology	J:107432
	stomach inflammation	J:107432
Aire^tm1.1Doi/Aire^tm1.1Doi Idd3^C57BL/6/Idd3^C57BL/6 Idd5^C57BL/10SnJ/Idd5^C57BL/10SnJ NOD.Cg-Idd3^C57BL/6 Idd5^C57BL/10SnJ Aire^tm1.1Doi/Doi	abnormal pancreas physiology	J:107432
	stomach inflammation	J:107432
Aire^tm1.1Doi/Aire^tm1.1Doi Il1r1^tm1Imx/Il1r1⁺ involves: 129S2/SvPas * 129S7/SvEvBrd * NOD	abnormal conjunctiva goblet cell morphology	J:163691
	abnormal cornea epithelium morphology	J:163691
	abnormal lacrimal gland morphology	J:163691
	abnormal ocular surface morphology	J:163691
	cornea opacity	J:163691
	dry eyes	J:163691
	keratoconjunctivitis	J:163691
	lacrimal gland inflammation	J:163691
Aire^tm1.1Doi/Aire^tm1.1Doi Il1r1^tm1Imx/Il1r1^tm1Imx involves: 129S2/SvPas * 129S7/SvEvBrd * NOD	abnormal conjunctiva goblet cell morphology	J:163691
	abnormal cornea epithelium morphology	J:163691
	cornea opacity	J:163691
	dry eyes	J:163691
	keratoconjunctivitis	J:163691
	lacrimal gland inflammation	J:163691
Aire^tm1.1Doi/Aire^tm1.1Doi Tg(Ins2-TFRC/OVA)296Wehi/0 Tg(TcraTcrb)425Cbn/0 involves: 129P2/OlaHsd * C57BL/6	abnormal T cell differentiation	J:135154
	decreased CD4-positive, alpha-beta T cell number	J:135154
Aire^tm1Mand/Aire⁺ Tg(Ins2-TFRC/OVA)296Wehi/0 Tg(TcraTcrb)425Cbn/0 involves: 129P2/OlaHsd * C57BL/6	abnormal T cell differentiation	J:135154
Aire^tm1Mmat/Aire^tm2Mmat Tg(TcraTcrb)425Cbn/? involves: BALB/c * C57BL/6 * CBA	abnormal thymus morphology	J:141379
	normal immune system phenotype	J:141379

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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