Dio2 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dio2
deiodinase, iodothyronine, type II
MGI:1338833

13 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Dio2^tm1Acb/Dio2^tm1Acb Tg(Cga-cre)3Sac/0 involves: C57BL/6J * SJL	abnormal thyroid hormone level	J:197623
	decreased total body fat amount	J:197623
	normal endocrine/exocrine gland phenotype	J:197623
	increased circulating thyroid-stimulating hormone level	J:197623
	increased circulating thyroxine level	J:197623
Dio2^tm1Acb/Dio2^tm1Acb Tg(GFAP-cre)25Mes/0 involves: FVB/N	decreased bone mineral density	J:197623
Dio2^tm1Acb/Dio2^tm1Acb Tg(GFAP-cre)25Mes/0 involves: FVB/N	normal endocrine/exocrine gland phenotype	J:197623
Dio2^tm1Vag/Dio2^tm1Vag involves: 129S7/SvEvBrd * C57BL/6	abnormal feces composition	J:104508
	abnormal thyroid-stimulating hormone level	J:72958
	abnormal urine homeostasis	J:104508
	decreased body weight	J:72958
	impaired adaptive thermogenesis	J:77694
	increased circulating thyroid-stimulating hormone level	J:72958
	increased circulating thyroxine level	J:72958
	increased thyroxine level	J:77694
	postnatal growth retardation	J:72958

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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