Mthfd2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
MGI:1338850

23 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mthfd2^{tm1b(EUCOMM)Wtsi}/Mthfd2⁺ C57BL/6N-Mthfd2^{tm1b(EUCOMM)Wtsi}/Bay	increased grip strength	J:211773
	increased heart left ventricle size	J:211773
	increased heart rate	J:211773
	thick ventricular wall	J:211773
Mthfd2^{tm1b(EUCOMM)Wtsi}/Mthfd2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Mthfd2^{tm1b(EUCOMM)Wtsi}/Bay	abnormal craniofacial morphology	J:211773
	abnormal cranium morphology	J:211773
	abnormal embryo development	J:211773
	abnormal embryo size	J:211773
	abnormal eye morphology	J:211773
	abnormal facial morphology	J:211773
	abnormal placenta size	J:211773
	abnormal umbilical cord morphology	J:211773
	embryonic growth retardation	J:211773
	microphthalmia	J:211773
	pale liver	J:211773
	pale yolk sac	J:211773
	pallor	J:211773
	prenatal lethality prior to heart atrial septation	J:211773
	preweaning lethality, complete penetrance	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Mthfd2^tm1Rmk/Mthfd2^tm1Rmk involves: 129S1/Sv * 129X1/SvJ * BALB/c	decreased embryo size	J:76786
	lethality throughout fetal growth and development, complete penetrance	J:76786
	pale liver	J:76786
	small liver	J:76786

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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