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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		St14
suppression of tumorigenicity 14 (colon carcinoma)
MGI:1338881
82 phenotypes from 6 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
St14Gt(RST485)Byg/St14+
involves: 129P2/OlaHsd * Black Swiss 		impaired skin barrier function J:108567
St14Gt(RST485)Byg/St14Gt(RST485)Byg
involves: 129P2/OlaHsd * Black Swiss 		abnormal hard palate morphology J:108567
abnormal tongue epithelium morphology J:108567
St14Gt(XM184)Byg/St14+
involves: 129P2/OlaHsd * Black Swiss 		impaired skin barrier function J:108567
St14Gt(XM184)Byg/St14Gt(XM184)Byg
involves: 129P2/OlaHsd * Black Swiss 		abnormal corneocyte morphology J:142708
abnormal epidermis stratum corneum morphology J:142708
abnormal hard palate morphology J:108567
abnormal tongue epithelium morphology J:108567
absent gastric milk in neonates J:142708
neonatal lethality, complete penetrance J:142708
St14tm1.1(KOMP)Vlcg/St14tm1.1(KOMP)Vlcg
C57BL/6N-St14tm1.1(KOMP)Vlcg/MbpMmucd 		abnormal embryo size J:211773
abnormal eye morphology J:211773
abnormal limb bud morphology J:211773
abnormal liver size J:211773
abnormal placenta size J:211773
embryonic growth retardation J:211773
pale liver J:211773
pale yolk sac J:211773
pallor J:211773
prenatal lethality prior to heart atrial septation J:211773
preweaning lethality, complete penetrance J:211773
St14tm1Bug/St14tm1Bug
involves: 129P2/OlaHsd 		abnormal epidermis stratum corneum morphology J:86715
abnormal epidermis stratum granulosum morphology J:86715
abnormal keratinocyte differentiation J:86715
abnormal stratum corneum lipid matrix formation J:86715
acanthosis J:86715
alopecia J:86715
enlarged corneocyte envelope J:86715
hyperkeratosis J:86715
impaired skin barrier function J:86715
impaired stratum corneum desquamation J:86715
scaly skin J:86715
thick epidermis J:86715
St14tm1Bug/St14tm1Bug
involves: 129P2/OlaHsd * Black Swiss 		abnormal corneocyte morphology J:87125, J:142708
abnormal epidermis stratum corneum morphology J:87125
abnormal hair shaft morphology J:87125
abnormal piliary canal morphology J:87125
abnormal skin appearance J:87125
abnormal snout morphology J:87125
abnormal vibrissa follicle morphology J:87125
absent gastric milk in neonates J:87125, J:142708
absent vibrissae J:87125
decreased body length J:87125
decreased body weight J:87125
decreased double-positive T cell number J:87125
decreased hair follicle number J:87125
dehydration J:87125
dry skin J:87125
impaired skin barrier function J:87125
increased thymocyte apoptosis J:87125
neonatal lethality, complete penetrance J:142708
postnatal lethality, complete penetrance J:87125
reddish skin J:87125
shiny skin J:87125
underdeveloped hair follicles J:87125
wrinkled skin J:87125
St14tm2Bug/St14tm2Bug
involves: 129P2/OlaHsd 		abnormal epidermis stratum corneum morphology J:86715
abnormal epidermis stratum granulosum morphology J:86715, J:153070
abnormal keratinocyte differentiation J:86715
abnormal stratum corneum lipid matrix formation J:86715
acanthosis J:86715
alopecia J:86715
enlarged corneocyte envelope J:86715
hyperkeratosis J:86715
impaired skin barrier function J:86715
impaired stratum corneum desquamation J:86715
scaly skin J:86715
thick epidermis J:86715
St14tm2Bug/St14tm3Bug
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA 		abnormal enterocyte morphology J:153070
abnormal enterocyte physiology J:153070
abnormal facial morphology J:153070
abnormal hair follicle morphology J:153070
abnormal large intestine crypts of Lieberkuhn morphology J:153070
abnormal large intestine morphology J:153070
absent digestive secretion J:153070
alopecia J:153070
cachexia J:153070
hyperkeratosis J:153070
intestinal edema J:153070
premature death J:153070
scaly skin J:153070
skin fibrosis J:153070
weight loss J:153070
St14tm2Bug/St14tm3Bug
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * FVB 		decreased salivation J:153070
normal digestive/alimentary phenotype J:153070
St14tm2Bug/St14tm3Bug
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * FVB/NJ * N:Black Swiss 		abnormal chemokine secretion J:213072
abnormal cytokine secretion J:213072
decreased CD4-positive, alpha-beta T cell number J:213072
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:213072
decreased CD8-positive, alpha-beta T cell number J:213072
decreased regulatory T cell number J:213072
decreased salivation J:213072
decreased tear production J:213072
increased anti-nuclear antigen antibody level J:213072
increased autoantibody level J:213072
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:213072
increased effector memory CD4-positive, alpha-beta T cell number J:213072
increased effector memory CD8-positive, alpha-beta T cell number J:213072
lacrimal gland inflammation J:213072
submandibular gland inflammation J:213072
St14tm2Bug/St14tm3Bug
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL 		abnormal colon morphology J:153070
abnormal enterocyte proliferation J:153070
absent digestive secretion J:153070
chronic diarrhea J:153070
colitis J:153070
decreased body size J:153070
normal digestive/alimentary phenotype J:153070
intestinal edema J:153070
megacolon J:153070
premature death J:153070
St14tm3Bug/St14tm3Bug
involves: 129S6/SvEvTac 		abnormal salivary gland physiology J:213072
decreased salivation J:213072
normal immune system phenotype J:213072
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory