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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Acvrl1
activin A receptor, type II-like 1
MGI:1338946
72 phenotypes from 7 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Acvrl1tm1Dgen/Acvrl1tm1Dgen
involves: 129P2/OlaHsd * C57BL/6 		abnormal aorta morphology J:186473
abnormal developmental vascular remodeling J:186473
abnormal dorsal aorta morphology J:186473
abnormal heart layer morphology J:186473
abnormal heart morphology J:186473
abnormal trabecula carnea morphology J:186473
abnormal visceral yolk sac morphology J:186473
abnormal vitelline vascular remodeling J:186473
abnormal vitelline vasculature morphology J:186473
embryonic growth retardation J:186473
embryonic lethality during organogenesis, complete penetrance J:101679, J:186473
enlarged heart J:186473
pericardial effusion J:186473
poor arterial differentiation J:186473
Acvrl1tm1Dyl/Acvrl1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		no abnormal phenotype detected J:65521, J:85366
Acvrl1tm1Dyl/Acvrl1tm1Dyl
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal angiogenesis J:65521
abnormal anterior cardinal vein morphology J:85366
abnormal cardinal vein morphology J:85366
abnormal definitive hematopoiesis J:65521, J:85366
abnormal dorsal aorta morphology J:85366
abnormal vascular smooth muscle morphology J:65521
abnormal vitelline vascular remodeling J:65521
abnormal vitelline vasculature morphology J:65521
absent atrioventricular cushions J:85366
arteriovenous malformation J:65521
dilated dorsal aorta J:85366
embryonic growth arrest J:65521
embryonic lethality during organogenesis, complete penetrance J:65521
heart hypoplasia J:85366
increased vasodilation J:85366
Acvrl1tm1Enl/Acvrl1+
B6.Cg-Acvrl1tm1Enl 		abnormal cholinergic neuron morphology J:226550
abnormal circadian regulation of systemic arterial blood pressure J:226550
abnormal enzyme/coenzyme activity J:226550
abnormal physiological response to xenobiotic J:226550
abnormal sympathetic nervous system physiology J:226550
decreased circulating angiotensin II level J:226550
dilated brain ventricle J:226550
hypertension J:226550
increased circulating adrenaline level J:226550
increased circulating noradrenaline level J:226550
normal renal/urinary system phenotype J:226550
Acvrl1tm1Enl/Acvrl1+
involves: C57BL/6 		abnormal hepatobiliary system morphology J:82115
normal cardiovascular system phenotype J:82115
dilated liver sinusoidal space J:82115
enlarged liver J:82115
gastrointestinal hemorrhage J:82115
hemorrhage J:82115
premature death J:82115
telangiectasia J:82115
Acvrl1tm1Enl/Acvrl1tm1Enl
involves: C57BL/6 		abnormal angiogenesis J:61177
abnormal blood vessel morphology J:61177
abnormal endocardium morphology J:61177
abnormal intersomitic vessel morphology J:61177
abnormal myocardium layer morphology J:61177
abnormal vascular smooth muscle morphology J:61177
abnormal vitelline vasculature morphology J:61177
arteriovenous malformation J:61177
dilated dorsal aorta J:61177
dilated pharyngeal arch artery J:61177
dilated vasculature J:61177
embryonic growth retardation J:61177
embryonic lethality during organogenesis, complete penetrance J:61177
enlarged pericardium J:61177
microcephaly J:61177
Acvrl1tm1Spo/Acvrl1tm1Enl
involves: 129S4/SvJae * C57BL/6 		abnormal vascular development J:85877
embryonic lethality during organogenesis, complete penetrance J:85877
Acvrl1tm1Spo/Acvrl1tm1Spo
involves: 129S4/SvJae * C57BL/6 		abnormal vascular development J:85877
embryonic lethality during organogenesis, complete penetrance J:85877
Acvrl1tm1Spo/Acvrl1tm2Spo
involves: 129 * 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:130020
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
involves: 129 		cerebral arteriovenous malformation J:196810
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
involves: 129 * C57BL/6 * FVB/N 		no abnormal phenotype detected J:130020
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
involves: 129 * 129S1/Sv * 129X1/SvJ 		abnormal lung vasculature morphology J:154620
anemia J:154620
arteriovenous malformation J:154620
cachexia J:154620
decreased hematocrit J:154620
enlarged heart J:154620
gastrointestinal arteriovenous malformation J:154620
internal hemorrhage J:154620
lung hemorrhage J:154620
melena J:154620
premature death J:154620
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Acvrl1-cre)L1Spo/0
involves: 129 * FVB 		abnormal blood vessel morphology J:154620
abnormal brain vasculature morphology J:154620
abnormal lung vasculature morphology J:154620
arteriovenous malformation J:154620
gastrointestinal hemorrhage J:154620
hemorrhage J:154620
lung hemorrhage J:154620
postnatal lethality J:154620
pulmonary arteriovenous malformation J:154620
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Myh11-icre/ERT2)1Soff/0
involves: 129 * FVB/N 		normal cardiovascular system phenotype J:227170
Acvrl1tm2.1Spo/Acvrl1tm2.1Spo
Tg(Tal1-cre/ERT)1Jrg/0
involves: 129 * C57BL/6 		abnormal vascular wound healing J:227170
arteriovenous malformation J:227170
gastrointestinal arteriovenous malformation J:227170
large intestine hemorrhage J:227170
moribund J:227170
Acvrl1tm2.2Spo/Acvrl1tm2.2Spo
involves: 129 * C57BL/6 * FVB/N 		absent vitelline blood vessels J:130020
embryonic growth retardation J:130020
embryonic lethality during organogenesis, complete penetrance J:130020
hemorrhage J:130020
Acvrl1tm2Spo/Acvrl1tm2Spo
Tg(Acvrl1-cre)L1Spo/0
involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N 		abnormal dorsal aorta morphology J:130020
abnormal lung vasculature morphology J:130020
abnormal vitelline vasculature morphology J:130020
arteriovenous malformation J:130020
dilated vasculature J:130020
lethality throughout fetal growth and development, complete penetrance J:130020
vascular smooth muscle hypotrophy J:130020
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory