Muc2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Muc2
mucin 2
MGI:1339364

44 phenotypes from 7 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Muc2^eey/Muc2^eey C57BL/6-Muc2^eey	abnormal colon morphology	J:194148
	abnormal endoplasmic reticulum morphology	J:194148
	abnormal enterocyte proliferation	J:194148
	abnormal intestinal goblet cell morphology	J:194148
	abnormal large intestine crypts of Lieberkuhn morphology	J:194148
	abnormal mitochondrial crista morphology	J:194148
	dilated mitochondrion	J:194148
	ileum inflammation	J:194148
	increased endoplasmic reticulum stress	J:194148
	increased enterocyte apoptosis	J:194148
	increased interferon-gamma secretion	J:194148
	increased interleukin-1 beta secretion	J:194148
	increased leukocyte cell number	J:194148
	increased susceptibility to induced colitis	J:194148
	increased tumor necrosis factor secretion	J:194148
	melena	J:194148
	normal neoplasm	J:194148
	premature death	J:194148
	rectal prolapse	J:194148
Muc2^eey/Muc2^wnn C57BL/6-Muc2^eey/Muc2^wnn	abnormal intestine morphology	J:194148
Muc2^keny/Muc2^keny C57BL/6JAnu-Muc2^keny/AnuApb	abnormal digestive system physiology	J:104190
	diarrhea	J:104190
	enlarged lymph nodes	J:104190
Muc2^M1Btlr/Muc2⁺ C57BL/6J-Muc2^M1Btlr	increased susceptibility to induced colitis	J:150326
Muc2^M1Btlr/Muc2^M1Btlr C57BL/6J-Muc2^M1Btlr	increased susceptibility to induced colitis	J:150326
Muc2^m2Btlr/? C57BL/6J-Muc2^m2Btlr	increased susceptibility to induced colitis	J:159359
Muc2^m3Btlr/Muc2^m3Btlr C57BL/6J-Muc2^m3Btlr	increased susceptibility to induced colitis	J:254906
Muc2^tm1Avel/Muc2^tm1Avel involves: 129P2/OlaHsd * C57BL/6	abnormal cell migration	J:75047
	abnormal cell physiology	J:75047
	abnormal enterocyte morphology	J:216831
	abnormal enterocyte proliferation	J:75047
	abnormal intestinal goblet cell morphology	J:75047
	abnormal intestinal mucosa morphology	J:216831
	abnormal intestine morphology	J:216831
	abnormal intestine physiology	J:216831
	abnormal large intestine crypts of Lieberkuhn morphology	J:216831
	colitis	J:216831
	decreased enterocyte apoptosis	J:75047
	gastrointestinal hemorrhage	J:75047
	increased cell proliferation	J:75047
	increased intestinal adenocarcinoma incidence	J:75047
	large intestinal inflammation	J:216831
Muc2^wnn/Muc2⁺ C57BL/6-Muc2^wnn	abnormal intestinal goblet cell morphology	J:194148
	decreased hematocrit	J:194148
	increased susceptibility to induced colitis	J:194148
	rectal hemorrhage	J:194148
Muc2^wnn/Muc2^wnn C57BL/6-Muc2^wnn	abnormal colon morphology	J:194148
	abnormal digestive system physiology	J:194148
	abnormal endoplasmic reticulum morphology	J:194148
	abnormal enterocyte proliferation	J:194148
	abnormal intestinal absorption	J:104190
	abnormal intestinal goblet cell morphology	J:104190, J:194148
	abnormal intestinal mucosa morphology	J:194148
	abnormal intestine physiology	J:194148
	abnormal large intestine crypts of Lieberkuhn morphology	J:194148
	abnormal mitochondrial crista morphology	J:194148
	colitis	J:194148
	decreased colon length	J:194148
	decreased hematocrit	J:194148
	diarrhea	J:104190
	dilated mitochondrion	J:194148
	ileum inflammation	J:194148
	increased circulating triglyceride level	J:194148
	increased endoplasmic reticulum stress	J:194148
	increased enterocyte apoptosis	J:194148
	increased interferon-gamma secretion	J:194148
	increased interleukin-1 beta secretion	J:194148
	increased interleukin-13 secretion	J:194148
	increased leukocyte cell number	J:194148
	increased lymphocyte cell number	J:194148
	increased susceptibility to induced colitis	J:194148
	increased susceptibility to weight loss	J:194148
	increased susceptibility to xenobiotic induced morbidity/mortality	J:194148
	increased tumor necrosis factor secretion	J:194148
	intestinal ulcer	J:194148
	melena	J:194148
	normal neoplasm	J:194148
	premature death	J:194148
	rectal prolapse	J:104190, J:194148

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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