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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Neurod1
neurogenic differentiation 1
MGI:1339708
68 phenotypes from 6 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Neurod1m1Btlr/Neurod1m1Btlr
C57BL/6J-Neurod1m1Btlr 		head tossing J:255210
hyperactivity J:255210
Neurod1tm1.1Kan/Neurod1tm1.1Kan
Tg(Gabra6-cre)B1Lfr/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		normal nervous system phenotype J:101098
Neurod1tm1Jle/Neurod1tm1Jle
involves: 129S4/SvJaeSor * C57BL/6 		abnormal amacrine cell morphology J:51299
abnormal Muller cell morphology J:51299
abnormal retina apoptosis J:51299
abnormal retina bipolar cell morphology J:51299
hyperglycemia J:74715
postnatal lethality, complete penetrance J:74715
Neurod1tm1Jle/Neurod1tm1Jle
involves: 129S4/SvJaeSor * ICR 		increased retina apoptosis J:121047
Neurod1tm1Jle/Neurod1tm1Jle
Tg(RIP1-Neurod1)1Jle/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA 		abnormal cerebellar foliation J:74715
abnormal cerebellar granule layer morphology J:74715
abnormal cochlear sensory epithelium morphology J:66787
abnormal inner ear vestibular sensory neuron innervation pattern J:66787
abnormal motor coordination/balance J:74715
abnormal neuron differentiation J:74715
abnormal Purkinje cell morphology J:74715
abnormal vestibular ganglion morphology J:66787
abnormal vestibulocochlear ganglion morphology J:66787
absent cochlear ganglion J:66787
absent dentate gyrus J:74715
absent endocochlear potential J:66787
ataxia J:74715
deafness J:66787
decreased body weight J:74715
decreased Purkinje cell number J:74715
decreased sensory neuron number J:66787
normal hearing/vestibular/ear phenotype J:66787
impaired balance J:74715
postnatal growth retardation J:74715
reduced cochlear modiolus J:66787
small cerebellum J:74715
thin external granule cell layer J:74715
Neurod1tm1Kan/Neurod1tm1Kan
involves: 129P2/OlaHsd 		perinatal lethality, complete penetrance J:101098
Neurod1tm1Kan/Neurod1tm1Mjts
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		perinatal lethality, complete penetrance J:101098
Neurod1tm1Mjts/Neurod1tm1Mjts
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J 		abnormal brain wave pattern J:59932
abnormal cerebellum morphology J:59932
abnormal dentate gyrus morphology J:59932
abnormal head movements J:59932
abnormal hippocampus CA4 region morphology J:59932
abnormal hippocampus development J:59932
abnormal hippocampus granule cell layer J:59932
abnormal hippocampus granule cell morphology J:59932
abnormal hippocampus morphology J:59932
ataxia J:59932
circling J:59932
normal homeostasis/metabolism phenotype J:59932
hyperactivity J:59932
hyperglycemia J:59932
postnatal lethality, incomplete penetrance J:59932
seizures J:59932
sporadic seizures J:59932
tonic-clonic seizures J:59932
Neurod1tm1Mjts/Neurod1tm1Mjts
involves: 129S7/SvEvBrd * C57BL/6 		abnormal intestinal enteroendocrine cell morphology J:43010
abnormal intestinal mucosa morphology J:43010
abnormal pancreatic acinar cell morphology J:43010
abnormal pancreatic beta cell morphology J:43010
absent pancreatic islets J:43010
decreased body size J:43010
decreased pancreatic alpha cell number J:43010
decreased pancreatic beta cell number J:43010
decreased pancreatic delta cell number J:43010
dehydration J:43010
hyperglycemia J:43010
increased pancreas apoptosis J:43010
ketoaciduria J:43010
pancreatic acinar cell zymogen granule accumulation J:43010
postnatal lethality, complete penetrance J:43010
Neurod1tm1Mjts/Neurod1tm1Mjts
involves: 129X1/SvJ 		abnormal lung epithelium morphology J:137934
decreased solitary pulmonary neuroendocrine cell number J:137934
impaired lung alveolus development J:137934
increased number of pulmonary neuroendocrine bodies J:137934
overexpanded pulmonary alveolus J:137934
Tg(RIP1-Neurod1)1Jle/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA 		no abnormal phenotype detected J:74715
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory