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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Csf2
colony stimulating factor 2 (granulocyte-macrophage)
MGI:1339752
64 phenotypes from 2 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Csf2tm1Ard/Csf2tm1Ard
involves: 129P2/OlaHsd * C57BL/6 		abnormal alveolar macrophage morphology J:18747
abnormal fertility/fecundity J:53659
abnormal leukocyte physiology J:86386
abnormal lung morphology J:18747
abnormal MHC II cell surface expression on macrophages J:86386
abnormal ovulation J:86386
abnormal placenta development J:53659
abnormal pulmonary alveolus morphology J:18747
abnormal spleen size J:67766
abnormal uterus morphology J:53659
absent mature ovarian follicles J:86386
decreased body size J:53659
decreased circulating progesterone level J:86386
decreased fetal size J:53659
decreased litter size J:53659
decreased ovary weight J:86386
decreased trophoblast glycogen cell number J:53659
emphysema J:18747
fetal growth retardation J:53659
normal hematopoietic system phenotype J:18747
impaired luteinization J:86386
impaired macrophage chemotaxis J:86386
increased spongiotrophoblast size J:53659
increased susceptibility to bacterial infection J:18747, J:53659
increased susceptibility to fungal infection J:18747
increased susceptibility to parasitic infection J:67766
lung inflammation J:18747
lymphoid hyperplasia J:18747
maternal effect J:53659
perinatal lethality, incomplete penetrance J:53659
placental labyrinth hypoplasia J:53659
postnatal growth retardation J:53659
postnatal lethality, incomplete penetrance J:53659
prenatal lethality, incomplete penetrance J:53659
prolonged diestrus J:86386
prolonged estrous cycle J:86386
prolonged metestrus J:86386
pulmonary alveolar proteinosis J:18747
reduced fertility J:53659
Csf2tm1Mlg/Csf2tm1Mlg
B6.129S2-Csf2tm1Mlg 		abnormal abdominal fat pad morphology J:102499
abnormal lipid level J:102499
abnormal pancreatic islet morphology J:145518
normal behavior/neurological phenotype J:102499
decreased energy expenditure J:102499
increased abdominal adipose tissue amount J:102499
increased body weight J:102499
increased circulating free fatty acids level J:102499
increased circulating glucose level J:145518
increased circulating leptin level J:102499
increased circulating triglyceride level J:102499
increased food intake J:102499
increased gonadal fat pad weight J:102499
increased mesenteric fat pad weight J:102499
increased subcutaneous adipose tissue amount J:102499
increased total body fat amount J:102499
Csf2tm1Mlg/Csf2tm1Mlg
involves: 129S2/SvPas 		abnormal alveolar macrophage morphology J:17978
abnormal lung morphology J:17978
abnormal pulmonary alveolus morphology J:17978
decreased susceptibility to experimental autoimmune encephalomyelitis J:148120
normal hematopoietic system phenotype J:17978
lymphoid hyperplasia J:17978
normal mortality/aging J:17978
Csf2tm1Mlg/Csf2tm1Mlg
involves: 129S2/SvPas * BALB/c 		abnormal aorta collagen fibril morphology J:84697
abnormal aorta elastic fiber morphology J:84697
Csf2tm1Mlg/Csf2tm1Mlg
involves: 129S2/SvPas * C57BL/6 		abnormal circulating glucose level J:142440
abnormal mesenteric fat pad morphology J:142440
decreased circulating insulin level J:142440
enhanced gluconeogenesis J:142440
increased body weight J:142440
increased fat cell size J:142440
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory