Csf2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Csf2
colony stimulating factor 2 (granulocyte-macrophage)
MGI:1339752

34 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Csf1^op/Csf1^op Csf2^tm1Ard/Csf2^tm1Ard involves: 129P2/OlaHsd * C57BL/6	abnormal bone marrow morphology	J:19089
	abnormal pulmonary alveolus morphology	J:19089
	absent teeth	J:19089
	decreased leukocyte cell number	J:19089
	extramedullary hematopoiesis	J:19089
	increased hemoglobin content	J:19089
	increased neutrophil cell number	J:19089
	interstitial pneumonia	J:19089
	lung inflammation	J:19089
	osteopetrosis	J:19089
	polycythemia	J:19089
	premature death	J:19089
	pulmonary alveolar proteinosis	J:19089
Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv Tg(SIRPA)1Flv/0 Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} involves: 129S4/SvJae * BALB/cAnNTac	abnormal response to transplant	J:207289
Csf1^{tm1.1(CSF1)Flv}/Csf1^{tm1.1(CSF1)Flv} Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv Thpo^{tm1.1(TPO)Flv}/Thpo^{tm1.1(TPO)Flv} involves: 129S4/SvJae * BALB/cAnNTac	abnormal response to transplant	J:207289
Csf2/Il3^{tm1.1(CSF2,IL3)Flv}/Csf2/Il3^{tm1.1(CSF2,IL3)Flv} Il2rg^tm1.1Flv/Il2rg^tm1.1Flv Rag2^tm1.1Flv/Rag2^tm1.1Flv involves: 129S4/SvJae * BALB/cAnNCr * BALB/cAnNTac	abnormal response to transplant	J:168302
Csf2^tm1Dran/Csf2^tm1Dran Ifng^tm1Ts/Ifng^tm1Ts Il3^tm1Glli/Il3^tm1Glli involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	increased B cell derived lymphoma incidence	J:83086
	increased carcinoma incidence	J:83086
	increased eosinophil cell number	J:83086
	increased IgE level	J:83086
	increased IgG1 level	J:83086
	increased immunoglobulin level	J:83086
	increased inflammatory response	J:83086
	increased ovarian carcinoma incidence	J:83086
	postnatal lethality, incomplete penetrance	J:83086
	premature death	J:83086
Csf2^tm1Dran/Csf2^tm1Dran Il3^tm1Glli/Il3^tm1Glli B6.129S2-Csf2^tm1Dran Il3^tm1Glli	abnormal leukocyte physiology	J:83086
	abnormal surfactant secretion	J:83086
	decreased susceptibility to type IV hypersensitivity reaction	J:67404
	glomerulonephritis	J:83086
	increased anti-double stranded DNA antibody level	J:83086
	increased eosinophil cell number	J:67404
	lung inflammation	J:67404
Csf2^tm1Dran/Csf2^tm1Dran Il3^tm1Glli/Il3^tm1Glli C.129S2-Csf2^tm1Dran Il3^tm1Glli	abnormal surfactant secretion	J:67404
	decreased susceptibility to type IV hypersensitivity reaction	J:67404
	increased eosinophil cell number	J:67404
	lung inflammation	J:67404
Csf2^tm1Mlg/Csf2^tm1Mlg Ifng^tm1Ts/Ifng^tm1Ts Il3^tm1Glli/Il3^tm1Glli B6.129S-Csf2^tm1Mlg Il3^tm1Glli Ifng^tm1TsIfng^tm1Ts	normal homeostasis/metabolism phenotype	J:145518
	increased pituitary adenoma incidence	J:145518
Csf2^tm1Mlg/Csf2^tm1Mlg Il3^tm1Glli/Il3^tm1Glli B6.129S2-Csf2^tm1Mlg Il3^tm1Glli	abnormal pancreatic islet morphology	J:145518
	decreased pancreatic beta cell number	J:145518
	hyperglycemia	J:145518
	impaired glucose tolerance	J:145518

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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