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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Csf1
colony stimulating factor 1 (macrophage)
MGI:1339753
131 phenotypes from 3 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Csf1Mhdabap25/Csf1Mhdabap25
C3HeB/FeJ-Csf1Mhdabap25 		decreased circulating alkaline phosphatase level J:183993
Csf1op/Csf1op
B6;C3Fe a/a-Csf1op/J 		abnormal auditory brainstem response waveform shape J:35818
abnormal microglial cell morphology J:170081
abnormal neurite morphology J:35818
abnormal ovarian folliculogenesis J:30863
abnormal ovulation J:30863
abnormal postnatal growth J:170081
abnormal visual evoked potential J:35818
normal behavior/neurological phenotype J:170081
decreased macrophage cell number J:30863, J:147697
decreased mature ovarian follicle number J:30863
decreased physiological sensitivity to xenobiotic J:147697
decreased tertiary ovarian follicle number J:30863
impaired granulosa cell differentiation J:30863
impaired macrophage chemotaxis J:147697
Csf1op/Csf1op
B6C3Fe a/a-Csf1op/J 		abnormal auditory brainstem response J:19549
abnormal bone marrow cavity morphology J:19549, J:26978
abnormal bone marrow cell morphology/development J:19549
abnormal bone marrow morphology J:73663
abnormal bone remodeling J:19549
abnormal branching of the mammary ductal tree J:20519
abnormal femur morphology J:18356
abnormal hematopoietic stem cell morphology J:19549
abnormal Kupffer cell morphology J:26978
abnormal lactation J:20519
abnormal Langerhans cell morphology J:112594
abnormal Langerhans cell physiology J:112594
abnormal long bone hypertrophic chondrocyte zone J:26978
abnormal mammary gland alveolus morphology J:20519
abnormal mammary gland development J:20519
abnormal mammary gland growth during pregnancy J:20519
abnormal masseter muscle morphology J:20589
abnormal microglial cell morphology J:49613
abnormal osteoclast differentiation J:4732, J:19549
abnormal osteoclast morphology J:26978
abnormal parietal bone morphology J:18356
abnormal perivascular macrophage morphology J:49613
abnormal spleen red pulp morphology J:26978
abnormal splenic cell ratio J:104139
abnormal splenocyte physiology J:19549
abnormal tibia morphology J:26978
abnormal uterine epithelium development J:26978
abnormal vestibular system physiology J:19549
abnormal visual evoked potential J:19549
absent Langerhans cell J:112594
amyloid beta deposits J:87261
decreased body weight J:73663, J:104139
decreased bone marrow cell number J:104139
decreased circulating testosterone level J:34371
decreased hippocampus pyramidal cell number J:87261
decreased leukocyte cell number J:104139
decreased macrophage cell number J:26978, J:104139
decreased monocyte cell number J:104139
decreased osteoclast cell number J:73663
domed cranium J:18356
endometrium hypoplasia J:26978
extramedullary hematopoiesis J:26978
increased bone trabecula number J:26978, J:73663
increased testis weight J:34371
myometrium hypoplasia J:26978
necrospermia J:34371
oligozoospermia J:34371
postnatal growth retardation J:73663
postnatal lethality, incomplete penetrance J:73663
reduced male fertility J:34371
thymus cortex hypoplasia J:26978
thymus medulla atrophy J:26978
Csf1op/Csf1op
C57BL/6J-Csf1op 		abnormal autopod morphology J:5634
abnormal bone marrow cavity morphology J:5634
abnormal bone structure J:5634
abnormal osteoblast physiology J:5634
abnormal osteoclast morphology J:5634
abnormal skeleton morphology J:110981
abnormal spleen red pulp morphology J:5634
abnormal thyroid parafollicular C-cell morphology J:5634
abnormal trabecular bone morphology J:5634
absent incisors J:5634
absent teeth J:110981
decreased circulating phosphate level J:5634
decreased macrophage cell number J:110981
decreased osteoclast cell number J:5634
domed cranium J:5634
osteopetrosis J:5634
osteoporosis J:110981
premature death J:5634
reduced fertility J:5634
round snout J:110981
short limbs J:5634
short tail J:5634
slow postnatal weight gain J:5634
Csf1op/Csf1op
involves: C3HeB/FeJ * C57BL/6J 		abnormal bone marrow cavity morphology J:5634
abnormal bone remodeling J:5634
abnormal branching of the mammary ductal tree J:20519
abnormal circulating calcium level J:5634
abnormal eating behavior J:40136
abnormal lactation J:20519
abnormal mammary gland development J:20519
abnormal mammary gland growth during lactation J:20519
abnormal mammary gland lobule morphology J:20519
abnormal mating frequency J:38039
abnormal osteoclast cell number J:33189
abnormal osteoclast differentiation J:38039
abnormal ovary morphology J:38039
abnormal ovulation J:38039
abnormal proestrus J:38039
abnormal sperm number J:34371
abnormal testis physiology J:34371
abnormal thyroid parafollicular C-cell morphology J:5634
absent teeth J:5634
decreased body weight J:40136
decreased circulating phosphate level J:5634
decreased circulating testosterone level J:34371
decreased corpora lutea number J:38039
decreased fertilization frequency J:38039
decreased litter size J:38039
decreased osteoclast cell number J:33189
decreased ovulation rate J:38039
decreased susceptibility to atherosclerosis J:40136
domed cranium J:5634
impaired embryo implantation J:38039
prolonged estrous cycle J:38039
reduced female fertility J:38039
reduced male mating frequency J:34371
Csf1tm1.2Sabw/Csf1tm1.2Sabw
involves: 129S4/SvJaeSor * C57BL/6 		abnormal bone marrow cavity morphology J:180199
abnormal bone structure J:180199
abnormal compact bone morphology J:180199
abnormal dental follicle morphology J:180199
abnormal dentin mineralization J:180199
abnormal Kupffer cell morphology J:180199
abnormal myeloid leukocyte morphology J:180199
abnormal osteoblast morphology J:180199
abnormal osteocyte dendritic process morphology J:180199
abnormal osteocyte lacuna morphology J:180199
abnormal osteocyte morphology J:180199
abnormal predentin morphology J:180199
abnormal tooth root development J:180199
abnormal trabecular bone morphology J:180199
decreased B cell number J:180199
decreased body weight J:180199
decreased bone marrow cell number J:180199
decreased bone mineralization J:180199
decreased bone resorption J:180199
decreased compact bone thickness J:180199
decreased length of long bones J:180199
decreased lymphocyte cell number J:180199
decreased macrophage cell number J:180199
decreased monocyte cell number J:180199
decreased osteoclast cell number J:180199
decreased spleen weight J:180199
decreased trabecular bone thickness J:180199
domed cranium J:180199
failure of tooth eruption J:180199
fragile skeleton J:180199
impaired osteoblast differentiation J:180199
increased bone mass J:180199
increased bone trabecula number J:180199
increased granulocyte number J:180199
increased long bone epiphyseal plate size J:180199
increased osteocyte apoptosis J:180199
increased T cell number J:180199
increased trabecular bone mass J:180199
increased trabecular bone volume J:180199
increased width of hypertrophic chondrocyte zone J:180199
osteopetrosis J:180199
osteosclerosis J:180199
postnatal growth retardation J:180199
small spleen J:180199
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory