P2rx7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

P2rx7
purinergic receptor P2X, ligand-gated ion channel, 7
MGI:1339957

24 phenotypes from 6 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
P2rx7^rs48804829-T/P2rx7^rs48804829-T C57BL/6	abnormal apoptosis	J:89513
P2rx7^rs48804829-T/P2rx7^rs48804829-T C57BL/6	abnormal cell death	J:89513
P2rx7^{tm1a(EUCOMM)Wtsi}/P2rx7^{tm1a(EUCOMM)Wtsi} C57BL/6N-P2rx7^{tm1a(EUCOMM)Wtsi}/Ieg	decreased circulating glycerol level	J:165965
P2rx7^{tm1b(EUCOMM)Wtsi}/P2rx7^{tm1b(EUCOMM)Wtsi} C57BL/6N-P2rx7^{tm1b(EUCOMM)Wtsi}/Ieg	abnormal lens morphology	J:211773
	cataract	J:211773
P2rx7^tm1Gab/P2rx7^tm1Gab B6.129P2-P2rx7^tm1Gab/J	abnormal mast cell physiology	J:190651
P2rx7^tm1Gab/P2rx7^tm1Gab either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * DBA/2)	abnormal cell death	J:89513
	abnormal interleukin-6 secretion	J:66835
	abnormal skeleton development	J:84145
	abnormal skeleton physiology	J:84145
	decreased body weight	J:84145
	decreased diameter of femur	J:89513
	decreased diameter of long bones	J:84145
	decreased diameter of tibia	J:89513
	decreased interleukin-1 beta secretion	J:66835
	increased osteoclast cell number	J:84145
P2rx7^tm1Gab/P2rx7^tm1Gab involves: 129P2/OlaHsd * C57BL/6	normal hearing/vestibular/ear phenotype	J:178055
P2rx7^tm1Ipch/P2rx7^tm1Ipch B6.Cg-P2rx7^tm1Ipch	abnormal inflammatory response	J:101945
P2rx7^tm1Ipch/P2rx7^tm1Ipch B6.Cg-P2rx7^tm1Ipch	abnormal pain threshold	J:101945
P2rx7^tm1Ipch/P2rx7^tm1Ipch involves: 129	normal immune system phenotype	J:97422
P2rx7^tm1Ipch/P2rx7^tm1Ipch involves: 129 * C57BL/6	abnormal macrophage physiology	J:118561
P2rx7^tm1Ipch/P2rx7^tm1Ipch involves: 129 * C57BL/6 * DBA	normal cardiovascular system phenotype	J:107324
P2rx7^tm1Lex/P2rx7^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	abnormal macrophage physiology	J:145020
	normal behavior/neurological phenotype	J:145020
	increased compensatory feeding amount	J:145020
	increased coping response	J:145020

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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