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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cth
cystathionine gamma lyase
MGI:1339968
35 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cthtm1b(EUCOMM)Hmgu/Cthtm1b(EUCOMM)Hmgu
C57BL/6N-Cthtm1b(EUCOMM)Hmgu/Ieg 		abnormal lens morphology J:211773
abnormal retina blood vessel morphology J:211773
abnormal retina morphology J:211773
abnormal retina vasculature morphology J:211773
decreased exploration in new environment J:211773
persistence of hyaloid vascular system J:211773
Cthtm1Iish/Cth+
B6.129-Cthtm1Iish/Iish 		increased circulating homocysteine level J:166184
Cthtm1Iish/Cthtm1Iish
B6.129-Cthtm1Iish/Iish 		abnormal circulating amino acid level J:166184
abnormal liver morphology J:166184
normal cardiovascular system phenotype J:166184
cystathioninuria J:166184
decreased circulating creatinine level J:166184
decreased circulating taurine level J:166184
decreased glutathione level J:166184
decreased lactate dehydrogenase level J:166184
decreased skeletal muscle fiber diameter J:166184
increased blood urea nitrogen level J:166184
increased cellular sensitivity to oxidative stress J:166184
increased circulating alanine transaminase level J:166184
increased circulating alkaline phosphatase level J:166184
increased circulating aspartate transaminase level J:166184
increased circulating homocysteine level J:166184
increased circulating serum albumin level J:166184
increased circulating triglyceride level J:166184
increased sensitivity to induced cell death J:166184
increased susceptibility to induced morbidity/mortality J:166184
increased susceptibility to induced muscular atrophy J:166184
increased susceptibility to weight loss J:166184
paralysis J:166184
postnatal growth retardation J:166184
Cthtm1Liwu/Cth+
involves: 129S/SvEvBrd * C57BL/6J 		decreased circulating cysteine level J:140705
hypertension J:140705
increased circulating homocysteine level J:140705
Cthtm1Liwu/Cthtm1Liwu
involves: 129S/SvEvBrd * C57BL/6J 		decreased circulating cysteine level J:140705
decreased physiological sensitivity to xenobiotic J:140705
decreased vasodilation J:140705
hypertension J:140705
increased circulating homocysteine level J:140705
increased physiological sensitivity to xenobiotic J:140705
normal renal/urinary system phenotype J:140705
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory