Pak2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pak2
p21 (RAC1) activated kinase 2
MGI:1339984

24 phenotypes from 6 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pak2^em1(IMPC)H/Pak2⁺ C57BL/6NTac-Pak2^em1(IMPC)H/H	increased circulating amylase level	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular volume	J:211773
Pak2^em1(IMPC)H/Pak2^em1(IMPC)H C57BL/6NTac-Pak2^em1(IMPC)H/H	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Pak2^{Gt(OST104058)Lex}/Pak2⁺ B6;129S5-Pak2^{Gt(OST104058)Lex}/J	abnormal actin cytoskeleton morphology	J:271067
	abnormal excitatory postsynaptic potential	J:271067
	abnormal neuronal migration	J:271067
	abnormal postsynaptic density morphology	J:271067
	abnormal response to social novelty	J:271067
	abnormal social investigation	J:271067
	normal behavior/neurological phenotype	J:271067
	decreased dendritic spine density	J:271067
	increased grooming behavior	J:271067
	increased stereotypic behavior	J:271067
	reduced long-term potentiation	J:271067
	social withdrawal	J:271067
Pak2^tm1.1Cher/Pak2^tm1.1Cher Not Specified	abnormal hematopoietic stem cell physiology	J:195865
Pak2^tm1.1Rjak/Pak2^tm1.1Rjak involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal cell death	J:171914
	increased fibroblast proliferation	J:171914
Pak2^tm1Dgen/Pak2^tm1Dgen involves: 129P2/OlaHsd * C57BL/6J	preweaning lethality, complete penetrance	J:82809
Pak2^tm1Rjak/Pak2^tm1Rjak involves: 129S1/Sv * 129X1/SvJ * C57BL/6	decreased embryo size	J:171914
	embryonic growth retardation	J:171914
	impaired somite development	J:171914
	open neural tube	J:171914
	preweaning lethality, complete penetrance	J:171914

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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