About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MGI:1340044
29 phenotypes from 4 alleles in 4 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Lrp8tm1Her/Lrp8tm1Her
involves: 129S6/SvEvTac 		abnormal brain development J:55691
abnormal cell death J:117956
abnormal cerebral cortex morphology J:105699
abnormal contextual conditioning behavior J:55691
abnormal dentate gyrus morphology J:55691, J:105699
abnormal hippocampus layer morphology J:105699
abnormal neuronal migration J:117956
abnormal Purkinje cell morphology J:55691
abnormal spatial learning J:100988
abnormal sperm flagellum morphology J:84102
abnormal sperm midpiece morphology J:84102
abnormal sperm mitochondrial sheath morphology J:84102
abnormal sperm physiology J:84102
abnormal spermatogenesis J:84102
asthenozoospermia J:84102
coiled sperm flagellum J:84102
hairpin sperm flagellum J:84102
kinked sperm flagellum J:84102
male infertility J:55691, J:84102
reduced cerebellar foliation J:55691
small cerebellum J:55691
Lrp8tm1Her/Lrp8tm1Her
involves: 129S6/SvEvTac * C57BL/6 		abnormal cerebral cortex morphology J:129338
abnormal hippocampus pyramidal cell layer J:129338
Lrp8tm1Her/Lrp8tm1Her
involves: 129S6/SvEvTac * C57BL/6J 		abnormal lateral ventricle morphology J:121846
abnormal postnatal subventricular zone morphology J:121846
abnormal rostral migratory stream morphology J:121846
Lrp8tm2.1Her/Lrp8tm2.1Her
involves: 129S6/SvEvTac 		abnormal cell death J:117956
decreased motor neuron number J:117956
neuron degeneration J:117956
Lrp8tm2.1Her/Lrp8tm2.1Her
involves: 129S6/SvEvTac * C57BL/6J 		no abnormal phenotype detected J:100988
Lrp8tm3Her/Lrp8tm3Her
involves: 129S6/SvEvTac * C57BL/6J 		abnormal contextual conditioning behavior J:100988
abnormal spatial learning J:100988
reduced long-term potentiation J:100988
Lrp8tm5Her/Lrp8tm5Her
Not Specified 		abnormal neuronal migration J:117956
neuron degeneration J:117956
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory