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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MGI:1340044
30 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lrp8tm1Her/Lrp8tm1Her
Pafah1b1tm1Awb/Pafah1b1+
involves: 129S6/SvEvTac * C57BL/6 		abnormal cerebral cortex morphology J:129338
abnormal hippocampus layer morphology J:129338
Lrp8tm1Her/Lrp8tm1Her
Vldlrtm1Her/Vldlr+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J 		abnormal lateral ventricle morphology J:121846
abnormal rostral migratory stream morphology J:121846
Lrp8tm1Her/Lrp8tm1Her
Vldlrtm1Her/Vldlrtm1Her
involves: 129S6/SvEvTac * 129S7/SvEvBrd 		abnormal brain development J:55691
abnormal cerebellar Purkinje cell layer J:105699
abnormal cerebellum development J:55691
abnormal cortical marginal zone morphology J:105699
abnormal dentate gyrus morphology J:105699
abnormal gait J:55691
abnormal hippocampus development J:55691
abnormal hippocampus morphology J:105699
ataxia J:55691
decreased body size J:55691
decreased brain size J:55691
delaminated cerebral cortex J:105699
lethality at weaning, complete penetrance J:55691
paralysis J:55691
small cerebellum J:55691
tremors J:55691
Lrp8tm1Her/Lrp8tm1Her
Vldlrtm1Her/Vldlrtm1Her
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal cerebral cortex morphology J:129338
Lrp8tm1Her/Lrp8tm1Her
Vldlrtm1Her/Vldlrtm1Her
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J 		abnormal cerebellum external granule cell layer morphology J:121846
abnormal neuronal precursor cell migration J:121846
abnormal olfactory bulb morphology J:121846
abnormal postnatal subventricular zone morphology J:121846
abnormal rostral migratory stream morphology J:121846
Lrp8tm4Her/Lrp8tm4Her
Not Specified 		abnormal cerebral cortex morphology J:105699
abnormal contextual conditioning behavior J:105699
abnormal dentate gyrus morphology J:105699
abnormal hippocampus layer morphology J:105699
abnormal neuronal migration J:117956
abnormal spatial reference memory J:105699
reduced male fertility J:105699
Lrp8tm4Her/Lrp8tm4Her
Vldlrtm1Her/Vldlrtm1Her
involves: 129S7/SvEvBrd 		abnormal cerebellar Purkinje cell layer J:105699
abnormal cortical marginal zone morphology J:105699
abnormal dentate gyrus morphology J:105699
abnormal gait J:105699
abnormal hippocampus morphology J:105699
ataxia J:105699
decreased body size J:105699
delaminated cerebral cortex J:105699
impaired balance J:105699
postnatal lethality, complete penetrance J:105699
small cerebellum J:105699
tremors J:105699
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory