Adam22 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Adam22
a disintegrin and metallopeptidase domain 22
MGI:1340046

12 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Adam22^tm1.1Mejr/Adam22^tm1.1Mejr H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	abnormal myelination	J:158973
	abnormal neuron morphology	J:158973
Adam22^tm1.1Mejr/Adam22^tm1.1Mejr Tg(Dhh-cre)1Mejr/0 involves: 129S4/SvJaeSor * FVB/N	normal nervous system phenotype	J:158973
Adam22^tm1Sag/Adam22^tm1Sag either: B6.Cg-Adam22^tm1Sag or (involves: C57BL/6 * C57BL/6N * CBA)	abnormal myelination	J:99692
	abnormal Schwann cell morphology	J:99692
	ataxia	J:99692
	convulsive seizures	J:99692
	decreased body size	J:99692
	decreased body weight	J:99692
	postnatal lethality, complete penetrance	J:99692
Adam22^tm1Sag/Adam22^tm1Sag involves: C57BL/6 * CBA	abnormal glial cell morphology	J:166449
	abnormal neuron morphology	J:158973
	decreased body weight	J:166449
	demyelination	J:158973, J:166449
	neonatal lethality, incomplete penetrance	J:166449

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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