Parp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Parp1
poly (ADP-ribose) polymerase family, member 1
MGI:1340806

49 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Parp1^{em1(IMPC)Ccpcz}/Parp1^{em1(IMPC)Ccpcz} C57BL/6NCrl-Parp1^{em1(IMPC)Ccpcz}/Ccpcz	abnormal eye morphology	J:211773
	abnormal seminal vesicle morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal uterus morphology	J:211773
	enlarged spleen	J:211773
	increased fasting circulating glucose level	J:211773
	microphthalmia	J:211773
	small seminal vesicle	J:211773
Parp1^{tm1b(EUCOMM)Hmgu}/Parp1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Parp1^{tm1b(EUCOMM)Hmgu}/Ics	abnormal retina inner nuclear layer morphology	J:211773
	decreased grip strength	J:211773
	decreased NK cell number	J:211773
	decreased total retina thickness	J:211773
	immune system phenotype	J:211773
	increased effector memory CD8-positive, alpha-beta T cell number	J:211773
	increased prepulse inhibition	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Parp1^tm1Hsmm/Parp1^tm1Hsmm involves: 129S4/SvJae	decreased physiological sensitivity to xenobiotic	J:53360
Parp1^tm1Jmdm/Parp1^tm1Jmdm involves: 129S2/SvPas	normal immune system phenotype	J:47993
Parp1^tm1Jmdm/Parp1^tm1Jmdm involves: 129S2/SvPas	increased mortality induced by ionizing radiation	J:170941
Parp1^tm1Jmdm/Parp1^tm1Jmdm involves: 129S2/SvPas * C57BL/6	abnormal cell cycle checkpoint function	J:41742
	abnormal DNA repair	J:41742
	abnormal inflammatory response	J:117701
	abnormal leukocyte migration	J:117701
	decreased body weight	J:41742
	decreased litter size	J:41742
	decreased susceptibility to noise-induced hearing loss	J:117701
	elevated level of mitotic sister chromatid exchange	J:41742
	increased apoptosis	J:41742
	increased mortality induced by gamma-irradiation	J:41742
	increased susceptibility to induced morbidity/mortality	J:41742
	induced chromosome breakage	J:41742
	prenatal lethality, incomplete penetrance	J:41742
Parp1^tm1Zqw/Parp1^tm1Zqw 129S-Parp1^tm1Zqw/J	abnormal microglial cell physiology	J:96548
	abnormal response/metabolism to endogenous compounds	J:96548
	decreased circulating creatinine level	J:95418
	decreased inflammatory response	J:95418
	decreased neuron apoptosis	J:96548
	decreased physiological sensitivity to xenobiotic	J:96548
	decreased renal tubule apoptosis	J:95418
	decreased susceptibility to kidney reperfusion injury	J:95418
	increased renal glomerular filtration rate	J:95418
Parp1^tm1Zqw/Parp1^tm1Zqw involves: 129/Sv * C57BL/6	decreased inflammatory response	J:94497
	decreased susceptibility to injury	J:94172
	enhanced wound healing	J:94172, J:94497
Parp1^tm1Zqw/Parp1^tm1Zqw involves: 129S2/SvPas	normal immune system phenotype	J:146533
Parp1^tm1Zqw/Parp1^tm1Zqw involves: 129S2/SvPas * C57BL/6	decreased cell proliferation	J:23942
	decreased neuron apoptosis	J:65747
	decreased susceptibility to dopaminergic neuron neurotoxicity	J:23942
	skin hyperplasia	J:23942
Parp1^tm2Zqw/Parp1^tm2Zqw either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)	abnormal inflammatory response	J:93479
	abnormal macrophage physiology	J:93479
	decreased circulating interleukin-1 beta level	J:93479
	decreased circulating tumor necrosis factor level	J:93479
	decreased inflammatory response	J:93479
	decreased susceptibility to endotoxin shock	J:93479

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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