Parp1 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Parp1
poly (ADP-ribose) polymerase family, member 1
MGI:1340806

15 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Brca1^tm2.1Cxd/Brca1^tm2.1Cxd Parp1^tm1Zqw/Parp1^tm1Zqw involves: 129S2/SvPas * 129S6/SvEvTac	abnormal centrosome morphology	J:139260
	abnormal chromosome morphology	J:139260
	aneuploidy	J:139260
	decreased cell proliferation	J:139260
	decreased embryo size	J:139260
	decreased telomere length	J:139260
	exencephaly	J:139260
	lethality throughout fetal growth and development, complete penetrance	J:139260
Parp1^tm1Jmdm/Parp1⁺ Parp2^tm1Jmdm/Parp2^tm1Jmdm involves: 129S2/SvPas * C57BL/6	aneuploidy	J:83371
	chromosomal instability	J:83371
	decreased litter size	J:83371
	embryonic growth arrest	J:83371
	embryonic lethality during organogenesis, incomplete penetrance	J:83371
	reduced female fertility	J:83371
Parp1^tm1Jmdm/Parp1^tm1Jmdm Parp2^tm1Jmdm/Parp2^tm1Jmdm involves: 129S2/SvPas * C57BL/6	embryonic growth arrest	J:83371
	embryonic lethality, complete penetrance	J:83371
Parp1^tm1Jmdm/Parp1^tm1Jmdm Parp3^tm1.2Ics/Parp3^tm1.2Ics involves: 129S2/SvPas * C57BL/6 * SJL	increased mortality induced by ionizing radiation	J:170941

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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