Pla2g2d Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pla2g2d
phospholipase A2, group IID
MGI:1341796

19 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pla2g2d^{tm1.1(KOMP)Vlcg}/Pla2g2d^{tm1.1(KOMP)Vlcg} C57BL/6N-Pla2g2d^{tm1.1(KOMP)Vlcg}/J	decreased leukocyte cell number	J:211773
	decreased urine magnesium level	J:211773
	hyperactivity	J:211773
Pla2g2d^tm1.1Mhg/Pla2g2d^tm1.1Mhg B6.Cg-Pla2g2d^tm1.1Mhg	normal immune system phenotype	J:197334
Pla2g2d^tm1.1Mhg/Pla2g2d^tm1.1Mhg B6NCrSlc.Cg-Pla2g2d^tm1.1Mhg	abnormal cytotoxic T cell physiology	J:229035
	abnormal dendritic cell migration	J:229035
	abnormal dendritic cell physiology	J:201008
	abnormal effector T cell morphology	J:201008
	abnormal lipid homeostasis	J:201008
	decreased interleukin-6 secretion	J:201008
	decreased susceptibility to Coronaviridae infection	J:229035
	decreased susceptibility to Coronaviridae infection induced morbidity/mortality	J:229035
	decreased tumor necrosis factor secretion	J:201008
	decreased unsaturated fatty acids level	J:229035
	normal immune system phenotype	J:201008
	increased CD4-positive, alpha-beta T cell number	J:201008, J:229035
	increased CD8-positive, alpha-beta T cell number	J:229035
	increased dendritic cell number	J:201008
	increased interferon-gamma secretion	J:229035
	increased susceptibility to type IV hypersensitivity reaction	J:201008

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24