Pla2g2d Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pla2g2d
phospholipase A2, group IID
MGI:1341796

19 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pla2g2d^{tm1.1(KOMP)Vlcg}/Pla2g2d^{tm1.1(KOMP)Vlcg} C57BL/6N-Pla2g2d^{tm1.1(KOMP)Vlcg}/J	decreased leukocyte cell number	J:211773
	decreased urine magnesium level	J:211773
	hyperactivity	J:211773
Pla2g2d^tm1.1Mhg/Pla2g2d^tm1.1Mhg B6.Cg-Pla2g2d^tm1.1Mhg	normal immune system phenotype	J:197334
Pla2g2d^tm1.1Mhg/Pla2g2d^tm1.1Mhg B6NCrSlc.Cg-Pla2g2d^tm1.1Mhg	abnormal cytotoxic T cell physiology	J:229035
	abnormal dendritic cell migration	J:229035
	abnormal dendritic cell physiology	J:201008
	abnormal effector T cell morphology	J:201008
	abnormal lipid homeostasis	J:201008
	decreased interleukin-6 secretion	J:201008
	decreased susceptibility to Coronaviridae infection	J:229035
	decreased susceptibility to Coronaviridae infection induced morbidity/mortality	J:229035
	decreased tumor necrosis factor secretion	J:201008
	decreased unsaturated fatty acids level	J:229035
	normal immune system phenotype	J:201008
	increased CD4-positive, alpha-beta T cell number	J:201008, J:229035
	increased CD8-positive, alpha-beta T cell number	J:229035
	increased dendritic cell number	J:201008
	increased interferon-gamma secretion	J:229035
	increased susceptibility to type IV hypersensitivity reaction	J:201008

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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