Lgr5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lgr5
leucine rich repeat containing G protein coupled receptor 5
MGI:1341817

19 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lgr5^{em1(IMPC)Kmpc}/Lgr5⁺ C57BL/6NTac-Lgr5^{em1(IMPC)Kmpc}/Kmpc	increased CD8-positive, CD25-positive alpha-beta T cell number	J:211773
	increased CD11b-high dendritic cell number	J:211773
	increased grip strength	J:211773
	no spontaneous movement	J:211773
Lgr5^{em1(IMPC)Kmpc}/Lgr5^{em1(IMPC)Kmpc} C57BL/6NTac-Lgr5^{em1(IMPC)Kmpc}/Kmpc	cleft palate	J:211773
	no spontaneous movement	J:211773
	preweaning lethality, complete penetrance	J:211773
Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal intestinal epithelium physiology	J:285672
	normal digestive/alimentary phenotype	J:285672
Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} involves: C57BL/6	normal digestive/alimentary phenotype	J:212415
	normal integument phenotype	J:212415
	perinatal lethality, complete penetrance	J:212415
	normal renal/urinary system phenotype	J:212415
Lgr5^tm1Ah/Lgr5^tm1Ah involves: 129S5/SvEvBrd	abnormal suckling behavior	J:127123
	abnormal tongue morphology	J:127123
	cyanosis	J:127123
	distended abdomen	J:127123
	neonatal lethality, complete penetrance	J:127123
	respiratory failure	J:127123
Lgr5^tm1Ah/Lgr5^tm1Ah involves: 129S5/SvEvBrd * C57BL/6	abnormal suckling behavior	J:94196
	absent gastric milk in neonates	J:94196
	cyanosis	J:94196
	distended abdomen	J:94196
	neonatal lethality, complete penetrance	J:94196
	respiratory failure	J:94196
	tongue ankylosis	J:94196
Lgr5^tm2.1Cle/Lgr5^tm2.1Cle Tg(Cyp1a1-cre)1Dwi/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	normal digestive/alimentary phenotype	J:174842

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24