Lgr5 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lgr5
leucine rich repeat containing G protein coupled receptor 5
MGI:1341817

45 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^tm1Tno/Apc^tm1Tno Elp3^tm1.1Tac/Elp3^tm1.1Tac Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * C57BL/6NTac	abnormal intestinal epithelium morphology	J:227334
	abnormal small intestinal crypt cell physiology	J:227334
	decreased tumor growth/size	J:227334
Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	increased intestinal adenoma incidence	J:227334
Apc^tm2.1Cip/Apc⁺ Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6	normal neoplasm	J:186084
Bptf^em1Zfa/Bptf^em1Zfa Ehf^em1Zfa/Ehf^em1Zfa Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal digestive system development	J:268724
	abnormal response to radiation	J:268724
Bptf^em1Zfa/Bptf^em1Zfa Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal digestive system development	J:268724
Cdc42^tm1Brak/Cdc42^tm1Brak Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	abnormal crypts of Lieberkuhn morphology	J:184563
	abnormal intestinal epithelium morphology	J:184563
	abnormal small intestinal villus morphology	J:184563
	absent Paneth cells	J:184563
	increased small intestinal crypt cell apoptosis	J:184563
Cdc42^tm1Brak/Cdc42^tm1Brak Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal crypts of Lieberkuhn morphology	J:184563
	absent Paneth cells	J:184563
Cdx2^tm2Fbe/Cdx2^tm2Fbe Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal cell migration	J:179732
	abnormal crypts of Lieberkuhn morphology	J:179732
	abnormal intestine physiology	J:179732
	abnormal Paneth cell physiology	J:179732
	increased Paneth cell number	J:179732
Col1a1^{tm1(tetO-SOX2)Mjm}/Col1a1⁺ Gt(ROSA)26Sor^tm1(tTA)Roos/Gt(ROSA)26Sor⁺ Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J	abnormal ileum crypts of Lieberkuhn morphology	J:199754
	abnormal intestine physiology	J:199754
	ectopic Paneth cells	J:199754
	increased cell proliferation	J:199754
Col1a1^{tm2(tetO-Pou5f1)Jae}/Col1a1⁺ Gt(ROSA)26Sor^tm1(tTA)Roos/Gt(ROSA)26Sor⁺ Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J	abnormal intestine physiology	J:199754
	abnormal small intestine crypts of Lieberkuhn morphology	J:199754
	increased cell proliferation	J:199754
Ctnnb1^tm1Mmt/Ctnnb1⁺ Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129X1/SvJ	intestine polyps	J:193873
Elp3^tm1.1Tac/Elp3^tm1.1Tac Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac	normal digestive/alimentary phenotype	J:227334
Gata6os^em1Zfa/Gata6os^em1Zfa Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	abnormal enterocyte physiology	J:268724
Gata6os^em1Zfa/Gata6os^em1Zfa Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal crypts of Lieberkuhn morphology	J:268724
	abnormal digestive system development	J:268724
	abnormal enterocyte physiology	J:268724
	abnormal response to radiation	J:268724
	abnormal small intestinal villus morphology	J:268724
Gata6os^em3Zfa/Gata6os^em3Zfa Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	abnormal enterocyte proliferation	J:268724
Lgr4^{tm1.1(cre/ERT2)Npa}/Lgr4^{tm1.1(cre/ERT2)Npa} Lgr5^{tm1.1(cre/ERT2)Npa}/Lgr5^{tm1.1(cre/ERT2)Npa} involves: C57BL/6	abnormal epidermal stem cell proliferation	J:212415
	abnormal hair follicle development	J:212415
	abnormal intestine development	J:212415
	abnormal intestine physiology	J:212415
	abnormal skin development	J:212415
	decreased hair follicle number	J:212415
	decreased kidney cell proliferation	J:212415
	perinatal lethality, complete penetrance	J:212415
	prenatal lethality, incomplete penetrance	J:212415
	normal renal/urinary system phenotype	J:212415
	thin epidermis	J:212415
Lgr4^tm1.1Knis/Lgr4^tm1.1Knis Lgr5^tm2.1Cle/Lgr5^tm2.1Cle Tg(Cyp1a1-cre)1Dwi/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal small intestinal crypt cell proliferation	J:174842
	decreased small intestinal villus size	J:174842
	premature death	J:174842
Lgr4^tm1.1Knis/Lgr4^tm1.1Knis Lgr5^tm2.1Cle/Lgr5^tm2.1Cle Tg(Vil1-cre/ERT2)23Syr/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal intestine physiology	J:174842
Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Lrig1^{tm1.1(cre/ERT2)Rjc}/Lrig1^{tm1.1(cre/ERT2)Rjc} involves: 129 * 129P2/OlaHsd * C57BL/6	abnormal crypts of Lieberkuhn morphology	J:186084
	increased intestinal adenoma incidence	J:186084
Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Mex3a^{tm1.1(KOMP)Vlcg}/Mex3a⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac	abnormal intestinal epithelium morphology	J:287423
	abnormal small intestine crypts of Lieberkuhn morphology	J:287423
	postnatal lethality, incomplete penetrance	J:287423
Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Stk26^tm2.1Zzh/Stk26^tm2.1Zzh involves: 129P2/OlaHsd * C57BL/6	abnormal enterocyte proliferation	J:322311
Lgr5^{tm1(cre/ERT2)Fjs}/Lgr5^{tm2(Hbegf/EGFP)Fjs} Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N	normal digestive/alimentary phenotype	J:177145
	neonatal lethality, complete penetrance	J:177145
Lgr5^{tm2(Hbegf/EGFP)Fjs}/Lgr5⁺ involves: C57BL/6N	normal digestive/alimentary phenotype	J:177145
Nrbp1^tm1.1Dja/Nrbp1^tm1.2Dja Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J	abnormal intestinal goblet cell morphology	J:184685
	abnormal intestine morphology	J:184685
	abnormal Paneth cell morphology	J:184685
	ectopic Paneth cells	J:184685
Rab11a^tm1.1Ngao/Rab11a^tm1.1Ngao Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJae	abnormal intestinal epithelium morphology	J:215917
Rnf43^tm1Cle/Rnf43^tm1Cle Znrf3^tm1Cle/Znrf3^tm1Cle Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd	increased intestinal adenoma incidence	J:186765
Rpap3^{tm1c(KOMP)Wtsi}/Rpap3^{tm1c(KOMP)Wtsi} Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * C57BL/6N	no abnormal phenotype detected	J:314346
Rprd1b^tm1Tshu/Rprd1b^tm1Tshu Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ Tg(Vil1-cre)20Syr/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal digestive system development	J:300857
Slc39a7^tm1.1Tfk/Slc39a7^tm1.1Tfk Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal intestine development	J:236234
	decreased Paneth cell number	J:236234
	normal digestive/alimentary phenotype	J:236234
	increased mortality induced by gamma-irradiation	J:236234
Tigar^{Gt(EUCE0047g05)Hmgu}/Tigar^{Gt(EUCE0047g05)Hmgu} Apc^tm1Tno/Apc^tm1Tno Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺ involves: 129P2/OlaHsd * 129S4/SvJae	decreased susceptibility to induced morbidity/mortality	J:198650
	decreased tumor growth/size	J:198650

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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