About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
MGI:1341830
47 phenotypes from 3 alleles in 4 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc
Tg(Ela1-cre)16Eps/0
involves: 129S6/SvEvTac 		abnormal exocrine pancreas morphology J:129974
abnormal pancreatic acinar cell morphology J:129974
abnormal pancreatic acinus morphology J:129974
acute pancreas inflammation J:129974
exocrine pancreas atrophy J:129974
normal homeostasis/metabolism phenotype J:129974
increased circulating amylase level J:129974
small pancreas J:129974
Eif2ak3tm1Drc/Eif2ak3tm1Drc
involves: 129S6/SvEvTac 		abnormal axial skeleton morphology J:76661
abnormal compact bone morphology J:76661
abnormal exocrine pancreas morphology J:129974
abnormal hindlimb morphology J:76661
abnormal insulin secretion J:76661
abnormal osteoblast morphology J:76661
abnormal osteoblast physiology J:76661
abnormal pancreatic acinar cell morphology J:76661
abnormal pancreatic alpha cell morphology J:76661
abnormal skeleton morphology J:76661
abnormal vertebrae development J:76661
abnormal vertebral body morphology J:76661
absent pancreatic alpha cells J:76661
absent pancreatic beta cells J:76661
decreased body size J:76661
decreased bone mineralization J:76661
decreased circulating insulin level J:76661
decreased compact bone thickness J:76661
decreased locomotor activity J:76661
decreased pancreatic beta cell number J:76661, J:129974
exocrine pancreatic insufficiency J:76661
hunched posture J:76661
hyperglycemia J:76661
impaired glucose tolerance J:76661
increased liver glycogen level J:76661
increased osteoblast apoptosis J:76661
osteoporosis J:76661
postnatal growth retardation J:76661
postnatal lethality, incomplete penetrance J:76661
prenatal lethality, incomplete penetrance J:76661
small pancreatic islets J:76661
Eif2ak3tm1Dron/Eif2ak3+
either: 129S6/SvEvTac-Eif2ak3tm1Dron or (involves: 129S6/SvEvTac * C57BL/6) 		impaired glucose tolerance J:70005
Eif2ak3tm1Dron/Eif2ak3tm1Dron
129S6/SvEvTac-Eif2ak3tm1Dron 		postnatal lethality, complete penetrance J:70005
Eif2ak3tm1Dron/Eif2ak3tm1Dron
involves: 129S6/SvEvTac 		abnormal cell physiology J:124971
increased physiological sensitivity to xenobiotic J:124971
Eif2ak3tm1Dron/Eif2ak3tm1Dron
involves: 129S6/SvEvTac * Swiss Webster 		abnormal exocrine pancreas morphology J:70005
abnormal pancreas physiology J:70005
abnormal pancreatic beta cell physiology J:70005
abnormal pancreatic islet morphology J:70005
decreased body weight J:70005
decreased circulating insulin level J:70005
decreased pancreatic beta cell number J:70005
exocrine pancreatic insufficiency J:70005
hyperglycemia J:70005
increased pancreatic alpha cell number J:70005
postnatal growth retardation J:70005
postnatal lethality J:70005
steatorrhea J:70005
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory