Rb1cc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rb1cc1
RB1-inducible coiled-coil 1
MGI:1341850

74 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Rb1cc1^em1(IMPC)Mbp/Rb1cc1⁺ C57BL/6N-Rb1cc1^em1(IMPC)Mbp/MbpMmucd	abnormal heart morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal placenta vasculature	J:211773
	embryonic growth retardation	J:211773
Rb1cc1^em1(IMPC)Mbp/Rb1cc1^em1(IMPC)Mbp C57BL/6N-Rb1cc1^em1(IMPC)Mbp/MbpMmucd	abnormal visceral yolk sac morphology	J:211773
	abnormal vitelline vasculature morphology	J:211773
	embryonic growth retardation	J:211773
	microphthalmia	J:211773
	preweaning lethality, complete penetrance	J:211773
Rb1cc1^tm1.1Guan/Rb1cc1^tm1.1Guan involves: 129P2/OlaHsd	abnormal enterocyte morphology	J:206181
Rb1cc1^tm1.1Guan/Rb1cc1^tm1.1Guan involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:114498
Rb1cc1^tm1.1Guan/Rb1cc1^tm1.1Guan Lyz2^tm1(cre)Ifo/Lyz2⁺ involves: 129P2/OlaHsd	normal immune system phenotype	J:235399
Rb1cc1^tm1.1Guan/Rb1cc1^tm1.1Guan Tg(BEST1-cre)1Jdun/0 involves: 129P2/OlaHsd * C57BL/6	abnormal Bruch membrane morphology	J:282249
	abnormal cone electrophysiology	J:282249
	abnormal retina photoreceptor layer morphology	J:282249
	abnormal retina pigment epithelium morphology	J:282249
	abnormal retina pigmentation	J:282249
	abnormal rod electrophysiology	J:282249
	decreased b-wave amplitude	J:282249
	disorganized retina layers	J:282249
	disorganized retina outer nuclear layer	J:282249
	impaired autophagy	J:282249
	increased susceptibility to age-related retinal degeneration	J:282249
	lipofuscinosis	J:282249
	microgliosis	J:282249
	retina pigment epithelium atrophy	J:282249
	thin retina outer nuclear layer	J:282249
	normal vision/eye phenotype	J:282249
Rb1cc1^tm1.1Guan/Rb1cc1^tm1.1Guan Tg(Mx1-cre)1Cgn/0 B6.Cg-Rb1cc1^tm1.1Guan Tg(Mx1-cre)1Cgn	abnormal hematopoietic stem cell morphology	J:167258
Rb1cc1^tm1.1Guan/Rb1cc1^tm1.1Guan Tg(SFTPC-cre)11Yo/0 involves: 129P2/OlaHsd * C57BL/6	abnormal alveolar lamellar body morphology	J:300057
	cyanosis	J:300057
	decreased alveolar lamellar body number	J:300057
	neonatal lethality, complete penetrance	J:300057
	respiratory distress	J:300057
	respiratory failure	J:300057
	small alveolar lamellar bodies	J:300057
Rb1cc1^tm1.1Guan/Rb1cc1^tm1.1Guan Tg(Tek-cre)12Flv/0 B6.Cg-Rb1cc1^tm1.1Guan Tg(Tek-cre)12Flv	abnormal autophagy	J:167258
	abnormal erythropoiesis	J:167258
	abnormal liver morphology	J:167258
	abnormal mitochondrial morphology	J:167258
	abnormal myelopoiesis	J:167258
	anemia	J:167258
	normal cardiovascular system phenotype	J:167258
	decreased erythrocyte cell number	J:167258
	decreased hematocrit	J:167258
	decreased hematopoietic stem cell number	J:167258
	decreased hemoglobin content	J:167258
	normal homeostasis/metabolism phenotype	J:167258
	increased erythroblast number	J:167258
	increased hematopoietic stem cell proliferation	J:167258
	increased neutrophil cell number	J:167258
	increased red blood cell distribution width	J:167258
	lethality throughout fetal growth and development, incomplete penetrance	J:167258
	pale liver	J:167258
	postnatal lethality, complete penetrance	J:167258
Rb1cc1^tm1.2Guan/Rb1cc1^tm1.2Guan involves: 129P2/OlaHsd * C57BL/6	abnormal heart morphology	J:114498
	abnormal heart ventricle morphology	J:114498
	abnormal hepatocyte morphology	J:114498
	abnormal liver morphology	J:114498
	abnormal myocardial trabeculae morphology	J:114498
	abnormal myocardium compact layer morphology	J:114498
	abnormal myocardium layer morphology	J:114498
	abnormal trabecula carnea morphology	J:114498
	congestive heart failure	J:114498
	decreased cell mass	J:114498
	decreased hepatocyte number	J:114498
	dilated heart left ventricle	J:114498
	dissociated hepatocytes	J:114498
	edema	J:114498
	increased fibroblast apoptosis	J:114498
	increased hepatocyte apoptosis	J:114498
	lethality throughout fetal growth and development, complete penetrance	J:114498
	liver degeneration	J:114498
	liver hemorrhage	J:114498
	pallor	J:114498
	thin myocardium	J:114498
	thin ventricular wall	J:114498

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24