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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stk11
serine/threonine kinase 11
MGI:1341870
168 phenotypes from 12 alleles in 25 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Amhr2tm3(cre)Bhr/Amhr2+
Stk11tm1Rdp/Stk11tm1Rdp
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal seminiferous tubule epithelium morphology J:187754
abnormal seminiferous tubule morphology J:187754
abnormal Sertoli cell morphology J:187754
abnormal spermatogenesis J:187754
abnormal testis morphology J:187754
decreased male germ cell number J:187754
decreased testis weight J:187754
increased Sertoli cell proliferation J:187754
normal neoplasm J:187754
small testis J:187754
Stk11tm1.1Arte/Stk11tm1.1Arte
involves: C57BL/6J 		abnormal cell physiology J:208379
abnormal lipid homeostasis J:208379
abnormal muscle physiology J:208379
normal homeostasis/metabolism phenotype J:208379
normal mortality/aging J:208379
normal reproductive system phenotype J:208379
Stk11tm1.1Gne/Stk11tm1.1Gne
involves: C57BL/6N 		abnormal branching involved in lung morphogenesis J:195229
abnormal lung bud morphology J:195229
abnormal lung development J:195229
lethality throughout fetal growth and development, complete penetrance J:195229
Stk11tm1.1Jish/Stk11+
involves: 129S7/SvEvBrd * C57BL/6J 		gastric polyps J:77213
increased adenoma incidence J:77213
increased intestinal adenoma incidence J:77213
Stk11tm1.1Jish/Stk11tm1.1Jish
involves: 129S7/SvEvBrd * C57BL/6J 		decreased embryo size J:77213
decreased somite size J:77213
embryonic growth retardation J:77213
embryonic lethality during organogenesis, complete penetrance J:77213
incomplete embryo turning J:77213
Stk11tm1.1Mlfr/Stk11+
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J 		abnormal intestine morphology J:104347
distended abdomen J:104347
enlarged liver J:104347
enlarged spleen J:104347
enlarged stomach J:104347
gastric polyps J:104347
increased hamartoma incidence J:104347
premature death J:104347
visceromegaly J:104347
Stk11tm1.1Mlfr/Stk11tm1.1Mlfr
involves: 129S7/SvEvBrd * C57BL/6J 		embryonic lethality, complete penetrance J:104347
Stk11tm1.1Rdp/Stk11+
involves: 129S6/SvEvTac * C57BL/6 * SJL 		no abnormal phenotype detected J:78818
Stk11tm1.1Rdp/Stk11+
Taglntm1(cre/ERT2)Feil/Tagln+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL 		normal digestive/alimentary phenotype J:134476
gastrointestinal tract polyps J:134476
increased gastrointestinal tumor incidence J:134476
intestinal obstruction J:134476
premature death J:134476
Stk11tm1.1Rdp/Stk11tm1.1Rdp
involves: 129S6/SvEvTac 		abnormal circulating glucose level J:174020
abnormal gluconeogenesis J:174020
normal homeostasis/metabolism phenotype J:174020
increased circulating glucose level J:174020
Stk11tm1.1Rdp/Stk11tm1.1Rdp
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal neoplasm J:124682
Stk11tm1.1Rdp/Stk11tm1.1Rdp
involves: 129S6/SvEvTac * FVB/N 		increased endometrial carcinoma incidence J:131865
Stk11tm1.1Rdp/Stk11tm1.1Rdp
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal axon extension J:305107
abnormal axon morphology J:305107
abnormal neuron physiology J:305107
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Isl1tm1(cre)Tmj/Isl1+
involves: 129S6/SvEvTac * 129X1/SvJ 		abnormal cerebral cortex morphology J:201695
normal behavior/neurological phenotype J:201695
decreased tumor-free survival time J:201695
increased gastrointestinal tumor incidence J:201695
normal nervous system phenotype J:201695
thin cerebral cortex J:201695
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Taglntm1(cre/ERT2)Feil/Tagln+
involves: 129S/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL 		gastrointestinal tract polyps J:134476
increased gastrointestinal tumor incidence J:134476
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Tg(KRT14-cre)1Ipc/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL 		abnormal hair follicle morphology J:131037
abnormal hair shaft morphology J:131037
cornea opacity J:131037
decreased body size J:131037
delayed hair appearance J:131037
increased squamous cell carcinoma incidence J:131037
reddish skin J:131037
sparse hair J:131037
waved hair J:131037
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL 		normal nervous system phenotype J:201695
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Tg(Pdx1-cre)89.1Dam/0
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N * ICR 		abnormal exocrine pancreas morphology J:134078
abnormal pancreatic acinar cell morphology J:134078
abnormal pancreatic acinus morphology J:134078
abnormal pancreatic islet morphology J:134078
decreased pancreatic alpha cell number J:134078
decreased pancreatic beta cell number J:134078
decreased pancreatic delta cell number J:134078
improved glucose tolerance J:134078
increased circulating glucose level J:134078
increased pancreas apoptosis J:134078
pancreas fibrosis J:134078
pancreas inflammation J:134078
small pancreas J:134078
small pancreatic islets J:134078
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Tg(PLAT-cre)116Sdu/0
involves: 129S6/SvEvTac 		abnormal alveolar process morphology J:236402
abnormal basicranium morphology J:236402
abnormal craniofacial morphology J:236402
abnormal nasal bone morphology J:236402
abnormal neurocranium morphology J:236402
abnormal palatine bone morphology J:236402
abnormal sphenoid bone morphology J:236402
abnormal suckling behavior J:236402
cleft secondary palate J:236402
decreased body height J:236402
decreased bone mineral density J:236402
decreased bone ossification J:236402
large anterior fontanelle J:236402
micrognathia J:236402
neonatal lethality, complete penetrance J:236402
short mandible J:236402
short snout J:236402
small basisphenoid bone J:236402
small cranium J:236402
small frontal bone J:236402
small maxilla J:236402
small parietal bone J:236402
small premaxilla J:236402
small presphenoid bone J:236402
small temporal bone squamous part J:236402
small vomer bone J:236402
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Tg(Sprr2f-cre)1Dcas/0
involves: 129S6/SvEvTac * FVB/N 		abnormal myometrium morphology J:158190
abnormal urinary bladder morphology J:158190
abnormal uterus size J:158190
hydronephrosis J:158190
increased endometrial carcinoma incidence J:158190
increased metastatic potential J:158190
increased uterus weight J:158190
peritoneal inflammation J:158190
premature death J:158190
sepsis J:158190
urinary bladder obstruction J:158190
Stk11tm1.1Rdp/Stk11tm1.2Rdp
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal neoplasm J:124682
Stk11tm1.1Sjm/Stk11tm1.1Sjm
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * C57BL/6 * SJL 		abnormal bone marrow cell physiology J:165090
Stk11tm1.1Sjm/Stk11tm1.1Sjm
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * SJL 		abnormal bone marrow cell morphology/development J:165090
abnormal bone marrow cell physiology J:165090
abnormal mitotic spindle morphology J:165090
aneuploidy J:165090
normal cellular phenotype J:165090
decreased bone marrow cell number J:165090
decreased erythrocyte cell number J:165090
decreased hematopoietic stem cell number J:165090
decreased leukocyte cell number J:165090
increased hematopoietic stem cell number J:165090
increased mitochondrial fission J:165090
pancytopenia J:165090
thrombocytopenia J:165090
thymus hypoplasia J:165090
Stk11tm1.2Rdp/Stk11+
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL 		gastrointestinal tract polyps J:134476
increased gastrointestinal tumor incidence J:134476
premature death J:134476
Stk11tm1.2Rdp/Stk11+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL 		abnormal digestive system physiology J:78818
colon polyps J:78818
gastric polyps J:78818
gastrointestinal tract polyps J:78818
increased hamartoma incidence J:78818
increased incidence of tumors by chemical induction J:131037
increased tumor incidence J:78818, J:131037
intestinal obstruction J:78818
premature death J:131037
Stk11tm1.2Rdp/Stk11+
involves: 129S6/SvEvTac * FVB/N 		increased endometrial carcinoma incidence J:131865
intestine polyps J:131865
Stk11tm1.2Rdp/Stk11tm1.2Rdp
involves: 129S6/SvEvTac 		abnormal cell differentiation J:141132
Stk11tm1.2Rdp/Stk11tm1.2Rdp
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL 		abnormal cell cycle J:78818
abnormal cell physiology J:78818
abnormal placenta development J:78818
abnormal vasculogenesis J:78818
embryonic lethality, complete penetrance J:78818
Stk11tm1Keis/Stk11tm1Keis
Not Specified 		normal growth/size/body region phenotype J:98513
normal homeostasis/metabolism phenotype J:98513
male infertility J:98513
perinatal lethality, incomplete penetrance J:98513
Stk11tm1Keis/Stk11tm1Keis
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd 		increased circulating interleukin-10 level J:191723
Stk11tm1Keis/Stk11tm1Keis
Tg(Ckmm-cre)5Khn/0
involves: FVB 		decreased muscle cell glucose uptake J:98513
normal growth/size/body region phenotype J:98513
male infertility J:98513
Stk11tm1Keis/Stk11tm1Keis
Tg(Cyp1a1-cre/ERT)1Dwi/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA 		gastric polyps J:169565
normal renal/urinary system phenotype J:169565
Stk11tm1Keis/Stk11tm1Keis
Tg(Pomc1-cre)1Gsb/0
involves: FVB/N 		abnormal gluconeogenesis J:170130
abnormal glycogen homeostasis J:170130
decreased fluid intake J:170130
normal endocrine/exocrine gland phenotype J:170130
normal homeostasis/metabolism phenotype J:170130
impaired glucose tolerance J:170130
insulin resistance J:170130
normal nervous system phenotype J:170130
Stk11tm1Mmt/Stk11+
involves: 129X1/SvJ 		gastric polyps J:76202
increased hamartoma incidence J:76202, J:107275
increased hepatocellular carcinoma incidence J:76202
increased tumor incidence J:76202
premature death J:76202
Stk11tm1Mmt/Stk11tm1Mmt
involves: 129X1/SvJ 		embryonic lethality, complete penetrance J:76202
Stk11tm1Tpm/Stk11+
involves: 129S7/SvEvBrd * C57BL/6 * CD-1 		decreased tumor incidence J:93361
gastric polyps J:93361
intestine polyps J:93361
Stk11tm1Tpm/Stk11+
Not Specified 		distended abdomen J:79074
duodenum polyps J:79074
gastric polyps J:79074
increased endometrial carcinoma incidence J:79074
increased hemangioma incidence J:79074
increased hepatocellular carcinoma incidence J:79074
increased liver adenoma incidence J:79074
intestinal obstruction J:79074
intestine polyps J:79074
premature death J:79074
Stk11tm1Tpm/Stk11tm1Tpm
Not Specified 		abnormal dorsal aorta morphology J:70892
abnormal embryo turning J:70892
abnormal head mesenchyme morphology J:70892
abnormal neural fold formation J:70892
abnormal neural tube closure J:70892
abnormal notochord morphology J:70892
abnormal placental labyrinth vasculature morphology J:70892
abnormal somite development J:70892
abnormal spongiotrophoblast layer morphology J:70892
abnormal vascular smooth muscle morphology J:70892
abnormal visceral yolk sac morphology J:70892
abnormal vitelline vasculature morphology J:70892
absent first pharyngeal arch J:70892
absent vitelline blood vessels J:70892
delayed chorioallantoic fusion J:70892
embryonic lethality during organogenesis, complete penetrance J:70892
first pharyngeal arch hypoplasia J:70892
placenta hemorrhage J:70892
small placenta J:70892
Stk11tm2.1Arte/Stk11tm2.1Arte
involves: C57BL/6J 		no abnormal phenotype detected J:208379
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory