About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hey2
hairy/enhancer-of-split related with YRPW motif 2
MGI:1341884
79 phenotypes from 7 alleles in 14 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Hey2tm1Eno/Hey2tm2Eno
Tg(Nkx2-5-cre)9Eno/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal heart left ventricle morphology J:121577
abnormal heart ventricle morphology J:121577
abnormal interventricular septum morphology J:121577
normal cardiovascular system phenotype J:121577
decreased cardiac muscle contractility J:121577
dilated heart right ventricle J:121577
enlarged heart J:121577
Hey2tm1Eno/Hey2tm2Eno
Tg(Tagln-cre)1Her/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		decreased cardiac muscle contractility J:121577
dilated heart right ventricle J:121577
perinatal lethality, incomplete penetrance J:121577
ventricular septal defect J:121577
Hey2tm1Eno/Hey2tm2Eno
Tg(Tek-cre)1Ywa/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		normal cardiovascular system phenotype J:121577
normal mortality/aging J:121577
Hey2tm1Gess/Hey2tm1Gess
B6.129P2-Hey2tm1Gess 		abnormal cardiovascular system morphology J:93980
abnormal heart shape J:93980
patent cardiac foramen ovale J:93980
perimembraneous ventricular septal defect J:93980
postnatal lethality, incomplete penetrance J:93980
tricuspid valve atresia J:93980
tricuspid valve stenosis J:93980
Hey2tm1Gess/Hey2tm1Gess
involves: 129P2/OlaHsd 		abnormal cardiac epithelial to mesenchymal transition J:133699
perimembraneous ventricular septal defect J:133699
Hey2tm1Gess/Hey2tm1Gess
involves: 129P2/OlaHsd * C57BL/6 		atrial septal defect J:79024
cardiac fibrosis J:79024
heart left ventricle hypertrophy J:79024
heart right ventricle hypertrophy J:79024
increased heart weight J:79024
myocardial fiber disarray J:79024
postnatal growth retardation J:79024
postnatal lethality, incomplete penetrance J:79024
ventricular septal defect J:79024
Hey2tm1Gess/Hey2tm1Gess
involves: 129P2/OlaHsd * CD-1 		postnatal lethality, incomplete penetrance J:93980
ventricular septal defect J:93980
Hey2tm1Kkb/Hey2tm1Kkb
involves: 129S7/SvEvBrd * C57BL/6 		abnormal aortic valve cusp morphology J:97120
abnormal atrioventricular valve morphology J:97120
abnormal endocardium morphology J:97120
abnormal mitral valve morphology J:97120
abnormal myocardial fiber morphology J:97120, J:216895
abnormal myocardium layer morphology J:216895
abnormal pulmonary alveolus morphology J:97120
abnormal pulmonary valve cusp morphology J:97120
abnormal semilunar valve morphology J:97120, J:216895
abnormal tricuspid valve morphology J:97120
abnormal ventricle myocardium morphology J:216895
abnormal Z line morphology J:216895
aortic valve regurgitation J:216895
aortic valve stenosis J:216895
atrioventricular valve regurgitation J:97120
cardiac fibrosis J:216895
congestive heart failure J:97120
decreased heart left ventricle muscle contractility J:97120, J:216895
decreased heart rate J:97120
dilated heart atrium J:97120
dilated heart left ventricle J:97120, J:216895
dilated heart right ventricle J:97120
enlarged heart J:97120
increased heart weight J:97120
increased lung weight J:97120
liver vascular congestion J:97120
mitral valve regurgitation J:97120
ostium secundum atrial septal defect J:97120
perimembraneous ventricular septal defect J:97120
postnatal growth retardation J:97120
postnatal lethality, complete penetrance J:97120
premature death J:216895
pulmonary edema J:97120
pulmonary vascular congestion J:97120
respiratory distress J:97120
thick aortic valve J:216895
thick pulmonary valve J:216895
thick semilunar valve J:216895
tricuspid valve regurgitation J:97120
tricuspid valve stenosis J:97120
Hey2tm1Mtc/Hey2tm1Mtc
B6.Cg-Hey2tm1Mtc 		abnormal atrioventricular valve morphology J:105823
abnormal blood vessel morphology J:105823
abnormal heart ventricle morphology J:105823
abnormal mitral valve morphology J:105823
abnormal pulmonary artery morphology J:105823
abnormal tricuspid valve morphology J:105823
decreased aorta wall thickness J:105823
dilated heart left ventricle J:105823
lethality at weaning, incomplete penetrance J:105823
thick mitral valve cusps J:105823
thin ventricular wall J:105823
ventricular septal defect J:105823
Hey2tm1Mtc/Hey2tm1Mtc
C.Cg-Hey2tm1Mtc 		abnormal atrioventricular valve morphology J:105823
abnormal heart septum morphology J:105823
abnormal mitral valve morphology J:105823
lethality at weaning, incomplete penetrance J:105823
tricuspid valve atresia J:105823
tricuspid valve stenosis J:105823
ventricular septal defect J:105823
Hey2tm1Mtc/Hey2tm1Mtc
involves: 129X1/SvJ 		absent interventricular septum membranous part J:80681
normal cardiovascular system phenotype J:80681
liver vascular congestion J:80681
perimembraneous ventricular septal defect J:80681
postnatal growth retardation J:80681
postnatal lethality, complete penetrance J:80681
pulmonary vascular congestion J:80681
visceral vascular congestion J:80681
Hey2tm1Mtc/Hey2tm1Mtc
involves: 129X1/SvJ * C57BL/6 		absent interventricular septum membranous part J:80681
cardiac interstitial fibrosis J:80681
cardiomyopathy J:80681
decreased body size J:80681
decreased cardiac muscle contractility J:80681
liver vascular congestion J:80681
perimembraneous ventricular septal defect J:80681
postnatal growth retardation J:80681
postnatal lethality, incomplete penetrance J:80681
pulmonary vascular congestion J:80681
visceral vascular congestion J:80681
Hey2tm1Uts/Hey2tm1Uts
either: (involves: 129X1/SvJ) or (involves: C57BL/6) 		abnormal heart development J:79025
abnormal heart shape J:79025
abnormal pulmonary valve cusp morphology J:79025
atrial septal defect J:79025
enlarged heart J:79025
heart left ventricle hypertrophy J:79025
heart right ventricle hypertrophy J:79025
muscular ventricular septal defect J:79025
overriding aortic valve J:79025
perimembraneous ventricular septal defect J:79025
postnatal lethality, incomplete penetrance J:79025
pulmonary artery stenosis J:79025
pulmonary valve stenosis J:79025
tricuspid valve atresia J:79025
Hey2tm2.1Mtc/Hey2tm2.1Mtc
Tg(Myh6-cre)2182Mds/0
involves: C57BL/6 * FVB/N * SJL 		abnormal myocardial fiber physiology J:186570
cardiac fibrosis J:186570
cardiac hypertrophy J:186570
congestive heart failure J:186570
decreased cardiac muscle contractility J:186570
increased response of heart to induced stress J:186570
Hey2tm2Eno/Hey2tm2Eno
129-Hey2tm2Eno 		neonatal lethality, complete penetrance J:121577
ventricular septal defect J:121577
Hey2tm2Eno/Hey2tm2Eno
involves: 129S6/SvEvTac * C57BL/6 		neonatal lethality, complete penetrance J:121577
ventricular septal defect J:121577
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory