Klf4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Klf4
Kruppel-like transcription factor 4 (gut)
MGI:1342287

64 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Klf4^{em1(IMPC)Kmpc}/Klf4^{em1(IMPC)Kmpc} C57BL/6NTac-Klf4^{em1(IMPC)Kmpc}/Kmpc	decreased grip strength	J:211773
Klf4^tm1.1Khk/Klf4^tm1.1Khk involves: 129S6/SvEvTac * C57BL/6	abnormal colon goblet cell morphology	J:76493
	abnormal intestinal epithelium morphology	J:76493
	neonatal lethality, complete penetrance	J:76493
Klf4^tm1Efu/Klf4^tm1Efu Not Specified	abnormal epidermis stratum corneum morphology	J:56495
	abnormal epidermis stratum granulosum morphology	J:56495
	abnormal suckling behavior	J:56495
	abnormal tongue epithelium morphology	J:56495
	dehydration	J:56495
	impaired skin barrier function	J:56495
	neonatal lethality, complete penetrance	J:56495
	parakeratosis	J:56495
Klf4^tm1Khk/Klf4^tm1Khk involves: 129S6/SvEvTac * C57BL/6	no abnormal phenotype detected	J:76493
Klf4^tm1Khk/Klf4^tm1Khk Lyz2^tm1(cre)Ifo/0 involves: 129P2/OlaHsd * 129S6/SvEvTac	decreased Ly6C low monocyte number	J:239509
Klf4^tm1Khk/Klf4^tm1Khk Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ involves: C57BL/6 * SJL	abnormal seminiferous tubule epithelium morphology	J:132612
	abnormal seminiferous tubule size	J:132612
	abnormal Sertoli cell development	J:132612
	abnormal testes secretion	J:132612
	decreased circulating testosterone level	J:132612
	normal reproductive system phenotype	J:132612
Klf4^tm1Khk/Klf4^tm1Khk Tg(ED-L2-cre)267Jkat/0 involves: 129S6/SvEvTac * C57BL/6	abnormal esophageal epithelium morphology	J:161868
	abnormal keratinocyte differentiation	J:161868
	abnormal keratinocyte morphology	J:161868
	abnormal skin morphology	J:161868
	abnormal tongue squamous epithelium morphology	J:161868
	focal ventral hair loss	J:161868
	skin lesions	J:161868
Klf4^tm1Khk/Klf4^tm1Khk Tg(Foxa3-cre)1Khk/0 involves: 129S6/SvEvTac * C57BL/6 * DBA	abnormal gastric chief cell morphology	J:97350
	abnormal gastric gland morphology	J:97350
	abnormal gastric parietal cell morphology	J:97350
	abnormal gastric surface mucous cell morphology	J:97350
	abnormal mucous neck cell morphology	J:97350
	abnormal stomach epithelium morphology	J:97350
	abnormal stomach mucosa morphology	J:97350
	gastric hypertrophy	J:97350
	preneoplasia	J:97350
Klf4^tm1Khk/Klf4^tm1Khk Tg(Klf4-cre/ERT)1Wai/0 involves: 129S6/SvEvTac * C57BL/6 * CBA	abnormal intestinal epithelium morphology	J:188101
	abnormal intestinal goblet cell morphology	J:188101
	ectopic Paneth cells	J:188101
	impaired wound healing	J:187932
	increased hair follicle cell proliferation	J:187932
	increased hair follicle number	J:189337
	increased incidence of tumors by chemical induction	J:189337
	increased keratinocyte adhesion	J:189337
	increased keratinocyte migration	J:189337
	increased keratinocyte proliferation	J:187932, J:189337
	increased Paneth cell number	J:188101
	thick epidermis suprabasal layer	J:189337
Klf4^tm1Khk/Klf4^tm1Khk Tg(Pax6-cre,GFP)1Pgr/0 involves: 129S6/SvEvTac * FVB/N	abnormal Bowman membrane morphology	J:117671
	abnormal cornea anterior stroma morphology	J:117671
	abnormal cornea endothelium morphology	J:117671
	abnormal cornea epithelium morphology	J:117671
	abnormal cornea stroma morphology	J:117671
	abnormal eye morphology	J:117671
	abnormal lens fiber morphology	J:117671
	absent conjunctiva goblet cells	J:117671
	acoria	J:117671
	blepharitis	J:117671
	decreased cornea epithelium thickness	J:117671
	increased cornea fragility	J:117671
	increased cornea stroma thickness	J:117671
	iris hyperplasia	J:117671
	lens vacuoles	J:117671
	microphthalmia	J:117671
	small lens	J:117671
	small pupil	J:117671

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