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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lat
linker for activation of T cells
MGI:1342293
95 phenotypes from 12 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Latem1(IMPC)Ics/Latem1(IMPC)Ics
C57BL/6N-Latem1(IMPC)Ics/Ics 		abnormal startle reflex J:211773
abnormal vitreous body morphology J:211773
increased circulating bilirubin level J:211773
Lattm1.1Mal/Lattm1.1Mal
involves: 129S2/SvPas 		abnormal B cell activation J:77098
abnormal gamma-delta T cell differentiation J:77098
abnormal immune serum protein physiology J:77098
abnormal immune system organ morphology J:77098
abnormal lymph node germinal center morphology J:125722
abnormal lymph node secondary follicle morphology J:125722
abnormal lymphocyte morphology J:77098
abnormal salivary gland morphology J:262891
abnormal spleen periarteriolar lymphoid sheath morphology J:125722
abnormal T cell selection J:77098
abnormal T cell subpopulation ratio J:77098
abnormal T-helper 2 physiology J:125722
albuminuria J:125722
chronic inflammation J:77098
decreased body weight J:262891
decreased double-positive T cell number J:77098
enlarged lymph nodes J:77098
enlarged spleen J:77098
glomerulonephritis J:125722
increased anti-chromatin antibody level J:125722
increased anti-erythrocyte antigen antibody level J:125722
increased anti-nuclear antigen antibody level J:125722
increased B cell number J:77098
increased blood urea nitrogen level J:125722
increased CD4-positive, alpha-beta T cell number J:77098, J:125722
increased eosinophil cell number J:77098
increased IgE level J:77098, J:125722
increased IgG1 level J:77098, J:125722, J:262891
increased IgM level J:125722
increased inflammatory response J:262891
increased interferon-gamma secretion J:77098
increased interleukin-4 secretion J:77098
increased memory T cell number J:77098
increased plasma cell number J:125722
increased spleen germinal center number J:125722
increased spleen weight J:262891
increased susceptibility to autoimmune hemolytic anemia J:125722
increased T cell proliferation J:77098
increased T-helper 2 cell number J:77098
kidney inflammation J:262891
liver inflammation J:125722
lung inflammation J:125722
pancreas fibrosis J:262891
pancreas inflammation J:262891
phlebitis J:262891
renal fibrosis J:262891
renal glomerular immunoglobulin deposits J:125722
salivary gland inflammation J:262891
spleen hyperplasia J:77098
thymus hypoplasia J:77098
Lattm1.1Mal/Lattm1.1Mal
involves: 129S2/SvPas * C57BL/6 		abnormal T cell proliferation J:131351
abnormal T-helper 2 physiology J:131351
Lattm1Bpay/Lattm1Bpay
involves: 129S2/SvPas 		abnormal platelet aggregation J:103904
abnormal T cell differentiation J:103904
arrested T cell differentiation J:103904
decreased double-negative T cell number J:103904
decreased T cell number J:103904
decreased thymocyte number J:103904
normal immune system phenotype J:103904
small thymus J:103904
Lattm1Les/Lattm1.1Wz
involves: C57BL/6 		abnormal effector T cell morphology J:147946
Lattm1Les/Lattm1.1Wz
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		abnormal effector T cell morphology J:147946
abnormal T cell differentiation J:147946
abnormal T cell physiology J:147946
decreased CD4-positive, alpha-beta T cell number J:147946
decreased CD8-positive, alpha-beta T cell number J:147946
decreased regulatory T cell number J:147946
decreased thymocyte number J:147946
increased double-positive T cell number J:147946
increased gamma-delta T cell number J:147946
small thymus J:147946
Lattm1Les/Lattm1.2Wz
involves: C57BL/6 * FVB/N 		absent T cells J:147946
arrested T cell differentiation J:147946
Lattm1Les/Lattm1Les
Not Specified 		abnormal T cell morphology J:54059
arrested T cell differentiation J:54059, J:116964
decreased double-negative T cell number J:54059
decreased T cell number J:54059
decreased thymocyte number J:54059
small thymus J:54059
Lattm2.1Lov/Lattm2.1Lov
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal T cell differentiation J:77695
decreased T cell number J:77695
small thymus J:77695
Lattm2.1Mal/Lattm2.1Mal
involves: 129S2/SvPas 		abnormal B cell activation J:94074
abnormal B cell differentiation J:94074
abnormal gamma-delta T cell differentiation J:94074
abnormal immune system organ morphology J:94074
abnormal lymphocyte morphology J:94074
abnormal lymphopoiesis J:94074
abnormal mature gamma-delta T cell morphology J:94074
abnormal plasma cell morphology J:94074
abnormal spleen morphology J:94074
abnormal spleen periarteriolar lymphoid sheath morphology J:94074
abnormal spleen white pulp morphology J:94074
abnormal T cell activation J:94074
abnormal T-helper 2 cell morphology J:94074
abnormal thymocyte activation J:94074
absent CD4-positive, alpha-beta T cells J:94074
absent CD8-positive, alpha-beta T cells J:94074
arrested T cell differentiation J:94074
decreased double-positive T cell number J:94074
enlarged lymph nodes J:94074
enlarged spleen J:94074
increased B cell number J:94074
increased IgE level J:94074
increased IgG1 level J:94074
increased immunoglobulin level J:94074
increased interleukin-4 secretion J:94074
increased mature gamma-delta T cell number J:94074
premature death J:94074
thymus hypoplasia J:94074
Lattm3.1Mal/Lattm3.1Mal
involves: 129S2/SvPas 		abnormal gamma-delta T cell differentiation J:94074
abnormal lymph node cell ratio J:94074
abnormal splenic cell ratio J:94074
abnormal thymocyte activation J:94074
abnormal thymus cell ratio J:94074
absent CD4-positive, alpha-beta T cells J:94074
absent CD8-positive, alpha-beta T cells J:94074
absent mature gamma-delta T cells J:94074
arrested T cell differentiation J:94074
decreased double-positive T cell number J:94074
decreased T cell number J:94074
increased T cell number J:94074
Lattm4.1Mal/Lattm4.1Mal
involves: 129P2/OlaHsd 		abnormal gamma-delta T cell differentiation J:94074
abnormal lymph node cell ratio J:94074
abnormal lymphocyte morphology J:94074
abnormal splenic cell ratio J:94074
abnormal thrombosis J:125744
abnormal thymocyte activation J:94074
abnormal thymus cell ratio J:94074
absent CD4-positive, alpha-beta T cells J:94074
absent CD8-positive, alpha-beta T cells J:94074
absent mature gamma-delta T cells J:94074
arrested T cell differentiation J:94074
decreased double-positive T cell number J:94074
decreased platelet aggregation J:125744
decreased T cell number J:94074
Lattm5.1Mal/Lattm5.1Mal
involves: C57BL/6 		arrested T cell differentiation J:152363
Lattm9Mal/Lattm9Mal
involves: C57BL/6 		abnormal B cell number J:205441
abnormal immune system morphology J:205441
abnormal immune system physiology J:205441
abnormal lymphopoiesis J:205441
increased T-helper 2 cell number J:205441
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory