Ikzf1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ikzf1
IKAROS family zinc finger 1
MGI:1342540

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ikzf1^tm1(Pax5)Mbu/Ikzf1⁺ Tg(Lck-cre)1Cwi/0 involves: 129P2/OlaHsd * C57BL/6	increased T cell derived lymphoma incidence	J:118111
Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu involves: 129P2/OlaHsd * C57BL/6	abnormal B cell number	J:80815
	abnormal dendritic cell morphology	J:80815
	abnormal T cell differentiation	J:80815
Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal T cell differentiation	J:80815
	arrested T cell differentiation	J:80815
	increased B cell number	J:80815
	increased early pro-B cell number	J:80815
	thymus hypoplasia	J:80815
Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal B cell differentiation	J:80815
	abnormal erythropoiesis	J:80815
	decreased double-positive T cell number	J:118111
	enlarged lymph nodes	J:118111
	enlarged spleen	J:118111
	enlarged thymus	J:118111
	increased B cell number	J:80815
	increased lymphoma incidence	J:118111
	increased pro-B cell number	J:80815
	increased T cell derived lymphoma incidence	J:118111
	premature death	J:118111
	thymus hypoplasia	J:118111
Ikzf1^{tm1.1(Pax5)Mbu}/Ikzf1⁺ Tcf3^tm1Mbu/Tcf3^tm1Mbu Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca	abnormal immunoglobulin heavy chain V(D)J recombination	J:137719
	normal immune system phenotype	J:137719
Ikzf1^tm1Kast/Ikzf1⁺ Tg(BCR/ABL)623Hkp/0 involves: 129S2/SvPas * C57BL/6 * CBA	increased acute lymphoblastic leukemia incidence	J:160846
Ikzf1^tm3.1Mbu/Ikzf1^tm3.1Mbu Cd79a^tm1(cre)Reth/Cd79a⁺ Rag2^tm1Fwa/Rag2^tm1Fwa involves: 129P2/OlaHsd * 129S/SvEv * BALB/c * C57BL/6 * SJL	decreased pro-B cell number	J:209928

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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