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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ikzf3
IKAROS family zinc finger 3
MGI:1342542
36 phenotypes from 2 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ikzf3tm1(KOMP)Vlcg/Ikzf3tm1(KOMP)Vlcg
C57BL/6N-Ikzf3tm1(KOMP)Vlcg/Rbrc 		decreased large unstained cell number J:211773
decreased leukocyte cell number J:211773
decreased lymphocyte cell number J:211773
increased neutrophil cell number J:211773
thrombocytopenia J:211773
Ikzf3tm1Kge/Ikzf3tm1Kge
involves: 129S4/SvJae 		decreased marginal zone B cell number J:69477
increased follicular B cell number J:69477
Ikzf3tm1Kge/Ikzf3tm1Kge
involves: 129S4/SvJae * C57BL/6 		abnormal B cell differentiation J:50626
abnormal blood urea nitrogen level J:81805
abnormal spleen marginal zone morphology J:50626
abnormal type III hypersensitivity reaction J:81805
autoimmune response J:81805
decreased B cell number J:81805
decreased IgG2b level J:50626
decreased IgG3 level J:50626
decreased IgM level J:50626
decreased naive B cell number J:81805
enlarged spleen J:50626
glomerulonephritis J:81805
increased anti-double stranded DNA antibody level J:81805
increased anti-histone antibody level J:81805
increased anti-nuclear antigen antibody level J:81805
increased anti-single stranded DNA antibody level J:81805
increased autoantibody level J:50626, J:81805
increased B cell derived lymphoma incidence J:50626
increased B cell proliferation J:50626
increased circulating creatinine level J:81805
increased IgE level J:50626
increased IgG1 level J:50626
increased IgG2a level J:50626
increased pre-B cell number J:50626
increased spleen germinal center number J:50626
increased T cell proliferation J:50626
increased urine protein level J:81805
premature death J:81805
renal glomerular immunoglobulin deposits J:81805
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory