Klf1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Klf1
Kruppel-like transcription factor 1 (erythroid)
MGI:1342771

28 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Klf1^Nan/Klf1⁺ either: B6.Cg-Klf1^Nan or WB.Cg-Klf1^Nan	abnormal erythrocyte morphology	J:162530
	anisocytosis	J:162530
	decreased erythrocyte cell number	J:162530
	decreased hematocrit	J:162530
	decreased hemoglobin content	J:162530
	decreased mean corpuscular hemoglobin	J:162530
	increased erythrocyte osmotic fragility	J:162530
	increased spleen weight	J:162530
	pallor	J:162530
	poikilocytosis	J:162530
	polychromatophilia	J:162530
	postnatal lethality, incomplete penetrance	J:162530
Klf1^Nan/Klf1⁺ involves: 101/H * C3H/HeH * PT	abnormal proximal convoluted tubule morphology	J:13933
	anemia	J:13933
	anisocytosis	J:13933
	decreased erythrocyte cell number	J:13933
	enlarged spleen	J:13933
	increased kidney iron level	J:13933
	increased liver iron level	J:13933
	increased nucleated erythrocyte cell number	J:13933
	increased spleen iron level	J:13933
Klf1^Nan/Klf1^Nan involves: 101/H * C3H/HeH * PT	embryonic lethality during organogenesis, complete penetrance	J:13933
Klf1^Nan/Klf1^Nan involves: 101/H * C3H/HeH * PT	impaired hematopoiesis	J:13933
Klf1^tm1.1Ryan/Klf1^tm1.1Ryan involves: 129S4/SvJae * C57BL/6 * C57BL/6J	normal hematopoietic system phenotype	J:204029
Klf1^tm1Nimr/Klf1^tm1Nimr either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * FVB)	abnormal erythropoiesis	J:25650
	anemia	J:25650
	decreased hemoglobin content	J:25650
	embryonic lethality during organogenesis, complete penetrance	J:25650
	erythroblastosis	J:25650
	impaired hematopoiesis	J:25650
	pale liver	J:25650
	small liver	J:25650
Klf1^tm1Sho/Klf1^tm1Sho involves: 129S4/SvJae * C57BL/6	abnormal embryonic erythrocyte morphology	J:25651
	abnormal erythrocyte morphology	J:25651
	abnormal erythropoiesis	J:25651
	anemia	J:25651
	lethality throughout fetal growth and development, complete penetrance	J:25651

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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