Klf2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Klf2
Kruppel-like transcription factor 2 (lung)
MGI:1342772

39 phenotypes from 6 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Klf2^tm1Hhn/Klf2^tm1Hhn involves: 129S4/SvJae * C57BL/6J	internal hemorrhage	J:228270
Klf2^tm1Hhn/Klf2^tm1Hhn involves: 129S4/SvJae * C57BL/6J	prenatal lethality, complete penetrance	J:228270
Klf2^tm1Jml/Klf2^tm1Jml either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * C57BL/6 * CD-1)	abnormal aorta tunica media morphology	J:44352
	abnormal blood vessel morphology	J:44352
	abnormal embryonic tissue morphology	J:44352
	abnormal vascular endothelial cell morphology	J:44352
	abnormal vascular smooth muscle morphology	J:44352
	anemia	J:44352
	aneurysm	J:44352
	decreased embryo size	J:44352
	embryo tissue necrosis	J:44352
	embryonic lethality during organogenesis, complete penetrance	J:44352
	hemorrhage	J:44352
	internal hemorrhage	J:44352
	microcephaly	J:44352
Klf2^tm1Khog/Klf2^tm1Khog involves: C57BL/6	no abnormal phenotype detected	J:151604
Klf2^tm1Ling/Klf2^tm1Ling involves: 129P2/OlaHsd	lethality throughout fetal growth and development, complete penetrance	J:127228
Klf2^tm1Ling/Klf2^tm1Ling involves: 129P2/OlaHsd * C57BL/6J	abnormal lung morphology	J:51402
	abnormal mandible morphology	J:51402
	anemia	J:51402
	embryonic growth retardation	J:51402
	embryonic lethality during organogenesis, complete penetrance	J:51402
	hemorrhage	J:51402
	normal immune system phenotype	J:51402
	impaired hematopoiesis	J:51402
	increased nucleated erythrocyte cell number	J:51402
	pale liver	J:51402
	pale yolk sac	J:51402
Klf2^tm1Mlkn/Klf2^tm1Mlkn Tg(Tek-cre)12Flv/? involves: C3H * C57BL/6	absent heartbeat	J:127228
	anemia	J:127228
	decreased systemic vascular resistance	J:127228
	detached epicardium	J:127228
	increased cardiac output	J:127228
	increased cardiac stroke volume	J:127228
	lethality throughout fetal growth and development, complete penetrance	J:127228
	pale yolk sac	J:127228
	pericardial effusion	J:127228
	thin myocardium	J:127228
Klf2^tm1Mlkn/Klf2^tm1Mlkn Tg(VAV1-cre)1Graf/0 Not Specified	absent T cells	J:127228
Klf2^tm2Ling/Klf2^tm2Ling Lyz2^tm1(cre)Ifo/0 involves: 129P2/OlaHsd * 129S6/SvEvTac	decreased Ly6C low monocyte number	J:239509
Klf2^tm2Ling/Klf2^tm2Ling Tg(Cd4-cre)1Cwi/? involves: 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal T cell differentiation	J:151604
	decreased T cell number	J:151604
	increased IgE level	J:151604
	increased IgG1 level	J:151604
	increased interleukin-4 secretion	J:151604
	increased single-positive T cell number	J:151604

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